MCL1
Gene Ontology Biological Process
- apoptotic mitochondrial changes [IDA]
- extrinsic apoptotic signaling pathway in absence of ligand [IMP, ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IBA]
- positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO]
- regulation of response to DNA damage stimulus [ISO]
- response to cytokine [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RBX1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.
Microtubules have pivotal roles in fundamental cellular processes and are targets of antitubulin chemotherapeutics. Microtubule-targeted agents such as Taxol and vincristine are prescribed widely for various malignancies, including ovarian and breast adenocarcinomas, non-small-cell lung cancer, leukaemias and lymphomas. These agents arrest cells in mitosis and subsequently induce cell death through poorly defined mechanisms. The strategies that resistant tumour cells use ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID