BAIT
SOCS1
Cish1, Cish7, JAB, SOCS-1, SSI-1
suppressor of cytokine signaling 1
GO Process (14)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- JAK-STAT cascade [IDA]
- cellular response to amino acid stimulus [IDA]
- cytokine-mediated signaling pathway [IDA, IMP]
- fat cell differentiation [IMP]
- negative regulation of JAK-STAT cascade [IMP]
- negative regulation of catalytic activity [IDA]
- negative regulation of insulin receptor signaling pathway [IDA]
- negative regulation of protein kinase activity [IBA]
- negative regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- regulation of JAK-STAT cascade [IMP]
- regulation of activation of JAK2 kinase activity [IMP]
- regulation of cytokine secretion [IMP]
- regulation of protein phosphorylation [IDA]
- regulation of tyrosine phosphorylation of Stat1 protein [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSPA1B
Hsp70, Hsp70-1, Hsp70.1, hsp68
heat shock protein 1B
GO Process (6)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome.
The regulation of cytokine signaling is critical for controlling cellular proliferation and activation during an immune response. SOCS-1 is a potent inhibitor of Jak kinase activity and of signaling initiated by several cytokines. SOCS-1 protein levels are tightly regulated, and recent data suggest that SOCS-1 may regulate the protein levels of some signaling proteins by the ubiquitin proteasome pathway; however, ... [more]
Mol. Cell. Biol. Oct. 01, 2004; 24(20);9092-101 [Pubmed: 15456882]
Throughput
- Low Throughput
Curated By
- BioGRID