NTRK2
Gene Ontology Biological Process
- brain-derived neurotrophic factor receptor signaling pathway [IDA, ISO]
- calcium-mediated signaling using intracellular calcium source [IMP]
- central nervous system neuron development [IMP]
- cerebral cortex development [IMP]
- feeding behavior [IMP]
- glutamate secretion [IPI]
- learning [IMP]
- long-term memory [ISO]
- long-term synaptic potentiation [IMP]
- mechanoreceptor differentiation [IMP]
- negative regulation of anoikis [IDA]
- negative regulation of neuron apoptotic process [ISO]
- neuromuscular junction development [IMP]
- neuron differentiation [IMP]
- neuron migration [IMP]
- neurotrophin signaling pathway [IDA, ISO]
- oligodendrocyte differentiation [IMP]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- peripheral nervous system neuron development [IMP]
- positive regulation of MAPK cascade [ISO]
- positive regulation of axonogenesis [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of glucocorticoid receptor signaling pathway [ISO]
- positive regulation of neuron projection development [IDA]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- protein autophosphorylation [ISO]
- regulation of MAPK cascade [ISO]
- regulation of Rac GTPase activity [IDA]
- regulation of dendrite development [ISO]
- regulation of metabolic process [IMP]
- regulation of neurotransmitter secretion [ISO]
- regulation of protein kinase B signaling [IMP]
- retinal rod cell development [IMP]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- brain-derived neurotrophic factor binding [IDA, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [ISO]
- neurotrophin binding [IDA, ISO]
- neurotrophin receptor activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- brain-derived neurotrophic factor binding [IDA, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [ISO]
- neurotrophin binding [IDA, ISO]
- neurotrophin receptor activity [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- axon terminus [ISO]
- cell [IPI]
- cell surface [ISO]
- cytoplasm [ISO]
- cytosol [IDA]
- dendrite [ISO]
- dendritic spine [ISO]
- endosome [IDA]
- excitatory synapse [ISO]
- growth cone [ISO]
- integral component of plasma membrane [ISO]
- intracellular [IMP]
- neuronal cell body [ISO]
- neuronal postsynaptic density [IDA]
- perikaryon [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
- postsynaptic membrane [IDA]
- presynaptic active zone [ISO]
- receptor complex [ISO]
- rough endoplasmic reticulum [ISO]
- terminal bouton [IDA]
SQSTM1
Gene Ontology Biological Process
- autophagy [ISO]
- positive regulation of macroautophagy [IBA, ISO]
- positive regulation of protein phosphorylation [ISO]
- protein heterooligomerization [ISO]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- regulation of nucleic acid-templated transcription [TAS]
- ubiquitin-dependent protein catabolic process [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Lysosomal accumulation of Trk protein in brain of GMâ‚ -gangliosidosis mouse and its restoration by chemical chaperone.
G(M1) -gangliosidosis is a fatal neurodegenerative disorder caused by deficiency of lysosomal acid β-galactosidase (β-gal). Accumulation of its substrate ganglioside G(M1) (G(M1) ) in lysosomes and other parts of the cell leads to progressive neurodegeneration, but underlying mechanisms remain unclear. Previous studies demonstrated an essential role for interaction of G(M1) with tropomyosin receptor kinase (Trk) receptors in neuronal growth, survival ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 5c.
Curated By
- BioGRID