UCHL1
Gene Ontology Biological Process
- adult walking behavior [IGI, IMP]
- axon target recognition [IMP]
- axon transport of mitochondrion [IMP]
- axonogenesis [IMP]
- cell proliferation [IMP]
- eating behavior [IGI]
- muscle fiber development [IGI]
- negative regulation of MAP kinase activity [ISO]
- neuromuscular process [IMP]
- protein deubiquitination [ISO]
- response to ischemia [IMP]
- sensory perception of pain [ISO]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TUBA1A
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons. The I93M mutation in ubiquitin C-terminal hydrolase L1 (UCH-L1) is associated with familial PD, and we have previously shown that the I93M UCH-L1-transgenic mice exhibit dopaminergic cell loss. Over 90% of neurodegenerative diseases, including PD, occur sporadically. However, the molecular mechanisms underlying sporadic PD as well as ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID