FAF1
Gene Ontology Biological Process
- cell death [ISO, ISS]
- cytoplasmic sequestering of NF-kappaB [ISO, ISS]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- positive regulation of protein complex assembly [ISO, ISS]
- regulation of cell adhesion [ISO]
- regulation of protein catabolic process [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TRPV1
Gene Ontology Biological Process
- behavioral response to pain [ISO]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [IDA, ISO]
- cellular response to ATP [IDA]
- cellular response to alkaloid [IMP]
- cellular response to cytokine stimulus [IDA]
- cellular response to growth factor stimulus [IEP]
- cellular response to nerve growth factor stimulus [IEP]
- cellular response to temperature stimulus [IEP]
- cellular response to tumor necrosis factor [IEP]
- detection of chemical stimulus involved in sensory perception of pain [ISO]
- diet induced thermogenesis [ISO]
- fever generation [ISO]
- glutamate secretion [IDA]
- inflammatory response [IEP]
- ion transmembrane transport [ISO]
- lipid metabolic process [ISO]
- microglial cell activation [IMP]
- negative regulation of establishment of blood-brain barrier [IMP]
- peptide secretion [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of gastric acid secretion [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- response to heat [IDA, ISO]
- response to organonitrogen compound [ISO]
- response to pH [IDA, IEP, ISO]
- response to pain [ISO]
- response to peptide hormone [IEP]
- sensory perception of mechanical stimulus [ISO]
- sensory perception of pain [ISO]
- signal transduction [IDA]
- smooth muscle contraction involved in micturition [ISO]
- temperature homeostasis [ISO]
- thermoception [ISO]
- urinary bladder smooth muscle contraction [ISO]
Gene Ontology Molecular Function- ATP binding [IDA]
- calcium channel activity [ISO]
- calcium-release channel activity [IMP]
- calmodulin binding [IPI]
- cation channel activity [IDA]
- cation transmembrane transporter activity [IDA]
- chloride channel regulator activity [IDA]
- excitatory extracellular ligand-gated ion channel activity [IDA]
- identical protein binding [IPI]
- ion channel activity [ISO]
- ligand-gated ion channel activity [IDA]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- transmembrane signaling receptor activity [IDA]
- ATP binding [IDA]
- calcium channel activity [ISO]
- calcium-release channel activity [IMP]
- calmodulin binding [IPI]
- cation channel activity [IDA]
- cation transmembrane transporter activity [IDA]
- chloride channel regulator activity [IDA]
- excitatory extracellular ligand-gated ion channel activity [IDA]
- identical protein binding [IPI]
- ion channel activity [ISO]
- ligand-gated ion channel activity [IDA]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- transmembrane signaling receptor activity [IDA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
TRPV1 recapitulates native capsaicin receptor in sensory neurons in association with Fas-associated factor 1.
TRPV1, a cloned capsaicin receptor, is a molecular sensor for detecting adverse stimuli and a key element for inflammatory nociception and represents biophysical properties of native channel. However, there seems to be a marked difference between TRPV1 and native capsaicin receptors in the pharmacological response profiles to vanilloids or acid. One plausible explanation for this overt discrepancy is the presence ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FAF1 TRPV1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| TRPV1 FAF1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID