TERF2IP
Gene Ontology Biological Process
- negative regulation of DNA recombination at telomere [ISS]
- negative regulation of telomere maintenance [IDA, IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- positive regulation of NF-kappaB transcription factor activity [ISS]
- protection from non-homologous end joining at telomere [IMP, ISS]
- protein localization to chromosome, telomeric region [IMP]
- regulation of double-strand break repair via homologous recombination [ISS]
- regulation of transcription, DNA-templated [ISS]
- telomere maintenance [IDA, TAS]
- telomere maintenance via telomerase [TAS]
- telomere maintenance via telomere lengthening [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UCHL1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Detection of low-affinity or transient interactions can be a bottleneck in our understanding of signaling networks. To address this problem, we developed an arrayed screening strategy based on protein complementation to systematically investigate protein-protein interactions in live human cells, and performed a large-scale screen for regulators of telomeres. Maintenance of vertebrate telomeres requires the concerted action of members of the ... [more]
Throughput
- High Throughput
Additional Notes
- BifC
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UCHL1 TERF2IP | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - | |
| UCHL1 TERF2IP | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 2388492 |
Curated By
- BioGRID