BAIT
TINF2
DKCA3, TIN2
TERF1 (TRF1)-interacting nuclear factor 2
GO Process (9)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of protein ADP-ribosylation [IGI]
- negative regulation of telomere maintenance via telomerase [IC, IGI]
- positive regulation of telomere maintenance [IMP]
- protein localization to chromosome [IC, IMP]
- protein localization to chromosome, telomeric region [IMP]
- telomere assembly [IMP]
- telomere maintenance [TAS]
- telomere maintenance via telomere lengthening [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRKCB
PKC-beta, PKCB, PRKCB1, PRKCB2
protein kinase C, beta
GO Process (17)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- B cell activation [ISS]
- B cell receptor signaling pathway [ISS]
- blood coagulation [TAS]
- histone H3-T6 phosphorylation [IDA]
- lipoprotein transport [TAS]
- negative regulation of glucose transport [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- platelet activation [TAS]
- positive regulation of B cell receptor signaling pathway [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- positive regulation of NF-kappaB transcription factor activity [ISS]
- positive regulation of angiogenesis [ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISS]
- protein phosphorylation [TAS]
- regulation of transcription from RNA polymerase II promoter [IMP]
- signal transduction [NAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Detection of low-affinity or transient interactions can be a bottleneck in our understanding of signaling networks. To address this problem, we developed an arrayed screening strategy based on protein complementation to systematically investigate protein-protein interactions in live human cells, and performed a large-scale screen for regulators of telomeres. Maintenance of vertebrate telomeres requires the concerted action of members of the ... [more]
Mol. Cell Proteomics Feb. 01, 2011; 10(2);M110.001628 [Pubmed: 21044950]
Throughput
- High Throughput
Additional Notes
- BifC
Curated By
- BioGRID