BAIT
POT1
CMM10, HPOT1
protection of telomeres 1
GO Process (11)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- DNA duplex unwinding [IDA]
- negative regulation of telomerase activity [IDA]
- negative regulation of telomere maintenance via telomerase [IMP]
- positive regulation of DNA strand elongation [IDA]
- positive regulation of helicase activity [IDA]
- positive regulation of telomerase activity [IDA]
- positive regulation of telomere maintenance via telomerase [IMP]
- telomere capping [IGI, IMP]
- telomere formation via telomerase [IDA]
- telomere maintenance [TAS]
- telomere maintenance via telomerase [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRMT7
protein arginine methyltransferase 7
GO Process (10)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- DNA methylation involved in gamete generation [ISS]
- histone arginine methylation [IBA, ISS]
- histone methylation [IDA]
- peptidyl-arginine methylation [IDA, IMP]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]
- peptidyl-arginine methylation, to symmetrical-dimethyl arginine [IDA, IMP]
- regulation of gene expression by genetic imprinting [ISS]
- regulation of protein binding [IC]
- regulation of transcription, DNA-templated [IBA]
- spliceosomal snRNP assembly [IMP]
Gene Ontology Molecular Function- S-adenosylmethionine-dependent methyltransferase activity [IDA]
- [myelin basic protein]-arginine N-methyltransferase activity [IDA]
- histone binding [IC]
- histone methyltransferase activity (H4-R3 specific) [ISS]
- histone-arginine N-methyltransferase activity [IDA]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- protein-arginine omega-N monomethyltransferase activity [IDA]
- protein-arginine omega-N symmetric methyltransferase activity [IDA, IMP]
- ribonucleoprotein complex binding [IPI]
- S-adenosylmethionine-dependent methyltransferase activity [IDA]
- [myelin basic protein]-arginine N-methyltransferase activity [IDA]
- histone binding [IC]
- histone methyltransferase activity (H4-R3 specific) [ISS]
- histone-arginine N-methyltransferase activity [IDA]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- protein-arginine omega-N monomethyltransferase activity [IDA]
- protein-arginine omega-N symmetric methyltransferase activity [IDA, IMP]
- ribonucleoprotein complex binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Detection of low-affinity or transient interactions can be a bottleneck in our understanding of signaling networks. To address this problem, we developed an arrayed screening strategy based on protein complementation to systematically investigate protein-protein interactions in live human cells, and performed a large-scale screen for regulators of telomeres. Maintenance of vertebrate telomeres requires the concerted action of members of the ... [more]
Mol. Cell Proteomics Feb. 01, 2011; 10(2);M110.001628 [Pubmed: 21044950]
Throughput
- High Throughput
Additional Notes
- BifC
Curated By
- BioGRID