BAIT
POT1
CMM10, HPOT1
protection of telomeres 1
GO Process (11)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- DNA duplex unwinding [IDA]
- negative regulation of telomerase activity [IDA]
- negative regulation of telomere maintenance via telomerase [IMP]
- positive regulation of DNA strand elongation [IDA]
- positive regulation of helicase activity [IDA]
- positive regulation of telomerase activity [IDA]
- positive regulation of telomere maintenance via telomerase [IMP]
- telomere capping [IGI, IMP]
- telomere formation via telomerase [IDA]
- telomere maintenance [TAS]
- telomere maintenance via telomerase [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FES
FPS
FES proto-oncogene, tyrosine kinase
GO Process (22)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- axon guidance [TAS]
- cell migration [IBA]
- cell proliferation [TAS]
- chemotaxis [IBA]
- epidermal growth factor receptor signaling pathway [IBA]
- innate immune response [IBA]
- multicellular organismal development [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of actin cytoskeleton reorganization [IMP]
- positive regulation of microtubule polymerization [IMP]
- positive regulation of myeloid cell differentiation [IMP]
- positive regulation of neuron projection development [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of cell adhesion [IMP]
- regulation of cell differentiation [IMP]
- regulation of cell motility [IMP]
- regulation of cell proliferation [IMP]
- regulation of cell shape [IMP]
- regulation of mast cell degranulation [IMP]
- regulation of vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Detection of low-affinity or transient interactions can be a bottleneck in our understanding of signaling networks. To address this problem, we developed an arrayed screening strategy based on protein complementation to systematically investigate protein-protein interactions in live human cells, and performed a large-scale screen for regulators of telomeres. Maintenance of vertebrate telomeres requires the concerted action of members of the ... [more]
Mol. Cell Proteomics Feb. 01, 2011; 10(2);M110.001628 [Pubmed: 21044950]
Throughput
- High Throughput
Additional Notes
- BifC
Curated By
- BioGRID