BAIT
POT1
CMM10, HPOT1
protection of telomeres 1
GO Process (11)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- DNA duplex unwinding [IDA]
- negative regulation of telomerase activity [IDA]
- negative regulation of telomere maintenance via telomerase [IMP]
- positive regulation of DNA strand elongation [IDA]
- positive regulation of helicase activity [IDA]
- positive regulation of telomerase activity [IDA]
- positive regulation of telomere maintenance via telomerase [IMP]
- telomere capping [IGI, IMP]
- telomere formation via telomerase [IDA]
- telomere maintenance [TAS]
- telomere maintenance via telomerase [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
IL1RN
DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4
interleukin 1 receptor antagonist
GO Process (6)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function- cytokine activity [IBA]
- interleukin-1 Type I receptor antagonist activity [IDA]
- interleukin-1 Type II receptor antagonist activity [IDA]
- interleukin-1 receptor antagonist activity [IDA, TAS]
- interleukin-1 receptor binding [IDA]
- interleukin-1, Type I receptor binding [IPI]
- interleukin-1, Type II receptor binding [IPI]
- cytokine activity [IBA]
- interleukin-1 Type I receptor antagonist activity [IDA]
- interleukin-1 Type II receptor antagonist activity [IDA]
- interleukin-1 receptor antagonist activity [IDA, TAS]
- interleukin-1 receptor binding [IDA]
- interleukin-1, Type I receptor binding [IPI]
- interleukin-1, Type II receptor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Detection of low-affinity or transient interactions can be a bottleneck in our understanding of signaling networks. To address this problem, we developed an arrayed screening strategy based on protein complementation to systematically investigate protein-protein interactions in live human cells, and performed a large-scale screen for regulators of telomeres. Maintenance of vertebrate telomeres requires the concerted action of members of the ... [more]
Mol. Cell Proteomics Feb. 01, 2011; 10(2);M110.001628 [Pubmed: 21044950]
Throughput
- High Throughput
Additional Notes
- BifC
Curated By
- BioGRID