BAIT
POT1
CMM10, HPOT1
protection of telomeres 1
GO Process (11)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- DNA duplex unwinding [IDA]
- negative regulation of telomerase activity [IDA]
- negative regulation of telomere maintenance via telomerase [IMP]
- positive regulation of DNA strand elongation [IDA]
- positive regulation of helicase activity [IDA]
- positive regulation of telomerase activity [IDA]
- positive regulation of telomere maintenance via telomerase [IMP]
- telomere capping [IGI, IMP]
- telomere formation via telomerase [IDA]
- telomere maintenance [TAS]
- telomere maintenance via telomerase [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RGS14
regulator of G-protein signaling 14
GO Process (19)
GO Function (5)
GO Component (10)
Gene Ontology Biological Process
- cell division [IMP]
- chromosome segregation [ISS]
- intracellular signal transduction [ISS]
- learning [ISS]
- long-term memory [ISS]
- long-term synaptic potentiation [ISS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of synaptic plasticity [ISS]
- nucleocytoplasmic transport [ISS]
- platelet-derived growth factor receptor signaling pathway [ISS]
- positive regulation of GTPase activity [IBA, IDA, TAS]
- positive regulation of neurogenesis [ISS]
- regulation of DNA-templated transcription in response to stress [ISS]
- regulation of G-protein coupled receptor protein signaling pathway [TAS]
- response to oxidative stress [ISS]
- spindle organization [IMP]
- visual learning [ISS]
- zygote asymmetric cell division [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Detection of low-affinity or transient interactions can be a bottleneck in our understanding of signaling networks. To address this problem, we developed an arrayed screening strategy based on protein complementation to systematically investigate protein-protein interactions in live human cells, and performed a large-scale screen for regulators of telomeres. Maintenance of vertebrate telomeres requires the concerted action of members of the ... [more]
Mol. Cell Proteomics Feb. 01, 2011; 10(2);M110.001628 [Pubmed: 21044950]
Throughput
- High Throughput
Additional Notes
- BifC
Curated By
- BioGRID