BAIT
TERF2
TRBF2, TRF2
telomeric repeat binding factor 2
GO Process (10)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- age-dependent telomere shortening [NAS]
- cellular senescence [NAS]
- negative regulation of telomere maintenance [IDA, IMP]
- negative regulation of telomere maintenance via semi-conservative replication [NAS]
- protection from non-homologous end joining at telomere [IMP]
- protein localization to chromosome, telomeric region [IMP]
- telomere capping [IMP, NAS]
- telomere maintenance [IMP, TAS]
- telomere maintenance via telomerase [IC]
- telomeric loop formation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BANP
BEND1, SMAR1, SMARBP1
BTG3 associated nuclear protein
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Detection of low-affinity or transient interactions can be a bottleneck in our understanding of signaling networks. To address this problem, we developed an arrayed screening strategy based on protein complementation to systematically investigate protein-protein interactions in live human cells, and performed a large-scale screen for regulators of telomeres. Maintenance of vertebrate telomeres requires the concerted action of members of the ... [more]
Mol. Cell Proteomics Feb. 01, 2011; 10(2);M110.001628 [Pubmed: 21044950]
Throughput
- High Throughput
Additional Notes
- BifC
Curated By
- BioGRID