MUL1
Gene Ontology Biological Process
- activation of JUN kinase activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- cellular response to exogenous dsRNA [IDA]
- mitochondrial fission [IMP]
- mitochondrion localization [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of chemokine (C-C motif) ligand 5 production [IMP]
- negative regulation of defense response to virus by host [IMP]
- negative regulation of innate immune response [IMP]
- negative regulation of mitochondrial fusion [IDA]
- negative regulation of protein kinase B signaling [IDA]
- negative regulation of type I interferon-mediated signaling pathway [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of mitochondrial fission [IDA]
- positive regulation of protein sumoylation [IDA]
- protein stabilization [IMP]
- protein ubiquitination [IDA]
- regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UBE2I
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- protein ubiquitination [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission.
The modification of proteins by the small ubiquitin-like modifier (SUMO) is known to regulate an increasing array of cellular processes. SUMOylation of the mitochondrial fission GTPase dynamin-related protein 1 (DRP1) stimulates mitochondrial fission, suggesting that SUMOylation has an important function in mitochondrial dynamics. The conjugation of SUMO to its substrates requires a regulatory SUMO E3 ligase; however, so far, none ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID