BAIT

MUL1

C1orf166, GIDE, MAPL, MULAN, RNF218, RP11-401M16.2
mitochondrial E3 ubiquitin protein ligase 1
Homo sapiens
PREY

DNM1L

DLP1, DRP1, DVLP, DYMPLE, EMPF, HDYNIV
dynamin 1-like
Homo sapiens

Biochemical Activity (Sumoylation)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission.

Braschi E, Zunino R, McBride HM

The modification of proteins by the small ubiquitin-like modifier (SUMO) is known to regulate an increasing array of cellular processes. SUMOylation of the mitochondrial fission GTPase dynamin-related protein 1 (DRP1) stimulates mitochondrial fission, suggesting that SUMOylation has an important function in mitochondrial dynamics. The conjugation of SUMO to its substrates requires a regulatory SUMO E3 ligase; however, so far, none ... [more]

EMBO Rep. Jul. 01, 2009; 10(7);748-54 [Pubmed: 19407830]

Throughput

  • Low Throughput

Curated By

  • BioGRID