MUL1
Gene Ontology Biological Process
- activation of JUN kinase activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- cellular response to exogenous dsRNA [IDA]
- mitochondrial fission [IMP]
- mitochondrion localization [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of chemokine (C-C motif) ligand 5 production [IMP]
- negative regulation of defense response to virus by host [IMP]
- negative regulation of innate immune response [IMP]
- negative regulation of mitochondrial fusion [IDA]
- negative regulation of protein kinase B signaling [IDA]
- negative regulation of type I interferon-mediated signaling pathway [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of mitochondrial fission [IDA]
- positive regulation of protein sumoylation [IDA]
- protein stabilization [IMP]
- protein ubiquitination [IDA]
- regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DNM1L
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- dynamin polymerization involved in mitochondrial fission [IDA]
- membrane fission involved in mitochondrial fission [IDA]
- membrane fusion [IDA]
- mitochondrial fission [IDA, IMP]
- mitochondrial fragmentation involved in apoptotic process [IMP]
- mitochondrion morphogenesis [IMP]
- necroptotic process [IMP]
- peroxisome fission [IDA, IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of mitochondrial fission [TAS]
- positive regulation of protein secretion [IDA]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- protein homotetramerization [IDA]
- regulation of mitochondrion organization [IMP]
- regulation of peroxisome organization [IMP]
- regulation of protein oligomerization [IDA]
- release of cytochrome c from mitochondria [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Sumoylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission.
The modification of proteins by the small ubiquitin-like modifier (SUMO) is known to regulate an increasing array of cellular processes. SUMOylation of the mitochondrial fission GTPase dynamin-related protein 1 (DRP1) stimulates mitochondrial fission, suggesting that SUMOylation has an important function in mitochondrial dynamics. The conjugation of SUMO to its substrates requires a regulatory SUMO E3 ligase; however, so far, none ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID