BAIT
GSK3B
glycogen synthase kinase 3 beta
GO Process (35)
GO Function (11)
GO Component (7)
Gene Ontology Biological Process
- ER overload response [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- axon guidance [TAS]
- canonical Wnt signaling pathway [IC, IDA]
- cellular response to interleukin-3 [ISS]
- circadian rhythm [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- epithelial to mesenchymal transition [IMP]
- extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- glycogen metabolic process [IDA]
- hippocampus development [IMP]
- innate immune response [TAS]
- intracellular signal transduction [IDA]
- negative regulation of NFAT protein import into nucleus [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of canonical Wnt signaling pathway [TAS]
- negative regulation of glycogen (starch) synthase activity [TAS]
- negative regulation of glycogen biosynthetic process [TAS]
- negative regulation of protein binding [IDA]
- negative regulation of protein complex assembly [IMP]
- negative regulation of type B pancreatic cell development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISS]
- positive regulation of protein binding [ISS]
- positive regulation of protein catabolic process [IC]
- positive regulation of protein complex assembly [IDA]
- positive regulation of protein export from nucleus [IDA]
- protein phosphorylation [IDA]
- regulation of microtubule-based process [IMP]
- superior temporal gyrus development [IMP]
Gene Ontology Molecular Function- NF-kappaB binding [IPI]
- RNA polymerase II transcription factor binding [IPI]
- beta-catenin binding [IPI]
- kinase activity [IDA, TAS]
- p53 binding [IDA]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISS]
- tau-protein kinase activity [IDA]
- ubiquitin protein ligase binding [IPI]
- NF-kappaB binding [IPI]
- RNA polymerase II transcription factor binding [IPI]
- beta-catenin binding [IPI]
- kinase activity [IDA, TAS]
- p53 binding [IDA]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISS]
- tau-protein kinase activity [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
PDE4D
ACRDYS2, DPDE3, HSPDE4D, PDE43, PDE4DN2, STRK1
phosphodiesterase 4D, cAMP-specific
GO Process (20)
GO Function (11)
GO Component (4)
Gene Ontology Biological Process
- T cell receptor signaling pathway [IMP]
- adrenergic receptor signaling pathway [ISS]
- adrenergic receptor signaling pathway involved in positive regulation of heart rate [IC]
- cAMP catabolic process [IDA, IGI, IMP]
- cAMP-mediated signaling [NAS]
- cellular response to cAMP [IDA]
- cellular response to epinephrine stimulus [IDA]
- establishment of endothelial barrier [ISS]
- negative regulation of heart contraction [ISS]
- negative regulation of peptidyl-serine phosphorylation [ISS]
- negative regulation of relaxation of cardiac muscle [ISS]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-2 production [IMP]
- positive regulation of interleukin-5 production [IMP]
- regulation of cardiac muscle cell contraction [ISS]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IC]
- regulation of heart rate [ISS]
- regulation of receptor activity [ISS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- regulation of ryanodine-sensitive calcium-release channel activity [ISS]
Gene Ontology Molecular Function- 3',5'-cyclic-AMP phosphodiesterase activity [IDA, IGI]
- 3',5'-cyclic-nucleotide phosphodiesterase activity [NAS]
- ATPase binding [IPI]
- beta-2 adrenergic receptor binding [ISS]
- cAMP binding [IDA]
- drug binding [IPI]
- enzyme binding [ISS]
- ion channel binding [IPI, ISS]
- protein binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- 3',5'-cyclic-AMP phosphodiesterase activity [IDA, IGI]
- 3',5'-cyclic-nucleotide phosphodiesterase activity [NAS]
- ATPase binding [IPI]
- beta-2 adrenergic receptor binding [ISS]
- cAMP binding [IDA]
- drug binding [IPI]
- enzyme binding [ISS]
- ion channel binding [IPI, ISS]
- protein binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D.
Calcineurin is a widely expressed and highly conserved Ser/Thr phosphatase. Calcineurin is inhibited by the immunosuppressant drug cyclosporine A (CsA) or tacrolimus (FK506). The critical role of CsA/FK506 as an immunosuppressant following transplantation surgery provides a strong incentive to understand the phosphatase calcineurin. Here we uncover a novel regulatory pathway for cyclic AMP (cAMP) signaling by the phosphatase calcineurin which ... [more]
Mol. Cell. Biol. Sep. 01, 2010; 30(18);4379-90 [Pubmed: 20647544]
Throughput
- Low Throughput
Curated By
- BioGRID