CACYBP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SIAH1A
Gene Ontology Biological Process
- male meiosis I [IMP]
- neuron apoptotic process [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- post-embryonic development [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein catabolic process [ISO]
- protein destabilization [ISO]
- protein ubiquitination [TAS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA, ISO]
- regulation of multicellular organism growth [IMP]
- spermatogenesis [IMP]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The modular structure of SIP facilitates its role in stabilizing multiprotein assemblies.
Siah-interacting protein (SIP) was identified as a novel adaptor that physically links the E3 ubiquitin ligase activity of Siah-1 with Skp1 and Ebi F-Box protein in the degradation of beta-catenin, a transcriptional activator of TCF/LEF genes. In this study, we have used solution NMR spectroscopy to characterize the domain structure of SIP, which includes a novel helical hairpin domain at ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID