KRT8
Gene Ontology Biological Process
- cell differentiation involved in embryonic placenta development [IGI]
- cell morphogenesis involved in differentiation [TAS]
- extrinsic apoptotic signaling pathway [IMP]
- hepatocyte apoptotic process [IMP]
- multicellular organismal development [TAS]
- response to hydrostatic pressure [ISO]
- response to other organism [IMP]
- sarcomere organization [ISO]
- tumor necrosis factor-mediated signaling pathway [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IDA, ISO]
- cell periphery [IDA]
- cell-cell junction [IDA]
- costamere [ISO]
- cytoplasm [ISO]
- dystrophin-associated glycoprotein complex [ISO]
- extracellular vesicular exosome [ISO]
- intermediate filament [IDA, ISO]
- intermediate filament cytoskeleton [ISO]
- keratin filament [ISO]
- nucleus [ISO]
- sarcolemma [IDA, ISO]
HSPA1B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The role of the ubiquitin-proteasome pathway in the formation of mallory bodies.
The dynamics of Mallory body (MB) formation are difficult to follow in vivo. Because of the lack of an in vitro mouse hepatocyte culture model, a cellular extract approach was developed. In this model an immunoprecipitate was obtained using an antibody to cytokeratin-8 (CK-8). The isolate contained a large number of compounds: CK-8, ubiquitin, a frameshift mutation of ubiquitin (UBB(+1)), ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID