KRT8
Gene Ontology Biological Process
- cell differentiation involved in embryonic placenta development [IGI]
- cell morphogenesis involved in differentiation [TAS]
- extrinsic apoptotic signaling pathway [IMP]
- hepatocyte apoptotic process [IMP]
- multicellular organismal development [TAS]
- response to hydrostatic pressure [ISO]
- response to other organism [IMP]
- sarcomere organization [ISO]
- tumor necrosis factor-mediated signaling pathway [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IDA, ISO]
- cell periphery [IDA]
- cell-cell junction [IDA]
- costamere [ISO]
- cytoplasm [ISO]
- dystrophin-associated glycoprotein complex [ISO]
- extracellular vesicular exosome [ISO]
- intermediate filament [IDA, ISO]
- intermediate filament cytoskeleton [ISO]
- keratin filament [ISO]
- nucleus [ISO]
- sarcolemma [IDA, ISO]
HSP90AA1
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- chaperone-mediated protein complex assembly [ISO]
- neuron migration [ISO]
- nitric oxide biosynthetic process [TAS]
- positive regulation of cell size [ISO]
- positive regulation of cytotoxic T cell differentiation [TAS]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of protein import into nucleus, translocation [ISO]
- protein import into mitochondrial outer membrane [ISO]
- protein refolding [TAS]
- regulation of catalytic activity [ISO]
- response to unfolded protein [TAS]
Gene Ontology Molecular Function- ATP binding [ISO]
- ATPase activity [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [ISO]
- TPR domain binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- mRNA binding [ISO]
- nitric-oxide synthase regulator activity [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- sulfonylurea receptor binding [ISO]
- unfolded protein binding [TAS]
- ATP binding [ISO]
- ATPase activity [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [ISO]
- TPR domain binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- mRNA binding [ISO]
- nitric-oxide synthase regulator activity [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- sulfonylurea receptor binding [ISO]
- unfolded protein binding [TAS]
Gene Ontology Cellular Component
- apical plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- brush border membrane [ISO]
- cell surface [ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO, TAS]
- extracellular matrix [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IDA]
- membrane [ISO]
- mitochondrion [ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The role of the ubiquitin-proteasome pathway in the formation of mallory bodies.
The dynamics of Mallory body (MB) formation are difficult to follow in vivo. Because of the lack of an in vitro mouse hepatocyte culture model, a cellular extract approach was developed. In this model an immunoprecipitate was obtained using an antibody to cytokeratin-8 (CK-8). The isolate contained a large number of compounds: CK-8, ubiquitin, a frameshift mutation of ubiquitin (UBB(+1)), ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID