GRB10
Gene Ontology Biological Process
- insulin receptor signaling pathway [ISO]
- insulin-like growth factor receptor signaling pathway [IPI]
- negative regulation of Wnt signaling pathway [IDA, ISO]
- negative regulation of glucose import [IMP]
- negative regulation of glycogen biosynthetic process [ISO, TAS]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of phosphorylation [IDA]
- positive regulation of phosphorylation [ISO]
- positive regulation of signal transduction [IPI]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO]
- response to insulin [ISO]
- signal transduction [TAS]
Gene Ontology Molecular Function
IRS2
Gene Ontology Biological Process
- brain development [IMP]
- cell proliferation [IMP]
- cellular response to insulin stimulus [IDA, ISO]
- insulin receptor signaling pathway [IMP, ISO]
- mammary gland development [IGI]
- negative regulation of B cell apoptotic process [IMP]
- negative regulation of kinase activity [IMP]
- negative regulation of plasma membrane long-chain fatty acid transport [ISO]
- positive regulation of B cell proliferation [IDA]
- positive regulation of cell migration [IGI]
- positive regulation of cell proliferation [IGI]
- positive regulation of fatty acid beta-oxidation [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucose metabolic process [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of insulin secretion [IMP]
- positive regulation of mesenchymal cell proliferation [IGI]
- regulation of lipid metabolic process [IBA]
- response to glucose [IDA]
- signal transduction [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.
The regulation of the metabolic insulin response by mouse growth factor receptor-binding protein 10 (Grb10) has been addressed in this report. We find mouse Grb10 to be a critical component of the insulin receptor (IR) signaling complex that provides a functional link between IR and p85 phosphatidylinositol (PI) 3-kinase and regulates PI 3-kinase activity. This regulatory mechanism parallels the established ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 7C.
Curated By
- BioGRID