CEBPA
Gene Ontology Biological Process
Gene Ontology Molecular Function
FBXW7
Gene Ontology Biological Process
- Notch signaling pathway [IDA]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IBA, ISO]
- cellular response to DNA damage stimulus [ISO]
- cellular response to UV [ISO]
- lung development [IMP]
- negative regulation of DNA endoreduplication [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of epidermal growth factor-activated receptor activity [ISO]
- positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO]
- positive regulation of proteasomal protein catabolic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- protein stabilization [ISO]
- protein ubiquitination [ISA, ISO]
- regulation of transcription, DNA-templated [IDA]
- sister chromatid cohesion [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation.
Adipose tissue controls body lipid and energy metabolism, as well as food intake, and abnormalities in adipose function play a central role in diseases such as obesity and type-2 diabetes. Adipocyte differentiation is controlled by a transcriptional cascade involving PPARgamma and members of the C/EBP family of transcription factors. Here, we demonstrate that C/EBPalpha is targeted for degradation by the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FBXW7 CEBPA | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID