ARNTL
Gene Ontology Biological Process
- circadian regulation of gene expression [IDA, IMP, ISO]
- circadian rhythm [IDA, IMP]
- negative regulation of TOR signaling [IMP]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of glucocorticoid receptor signaling pathway [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- oxidative stress-induced premature senescence [IMP]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of circadian rhythm [IMP]
- positive regulation of skeletal muscle cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IC, IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein import into nucleus, translocation [IDA]
- regulation of cell cycle [IMP]
- regulation of cellular senescence [IMP]
- regulation of hair cycle [ISO]
- regulation of insulin secretion [IMP]
- regulation of neurogenesis [IMP]
- regulation of protein catabolic process [IDA]
- regulation of transcription, DNA-templated [IDA, ISA]
- regulation of type B pancreatic cell development [IMP]
- response to redox state [IDA, ISO]
- spermatogenesis [IMP]
- transcription from RNA polymerase II promoter [IC]
Gene Ontology Molecular Function- DNA binding [IDA, IPI, ISO]
- E-box binding [IDA, ISO]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- aryl hydrocarbon receptor binding [ISO]
- bHLH transcription factor binding [IPI]
- core promoter binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISA]
- transcription factor binding [ISA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- DNA binding [IDA, IPI, ISO]
- E-box binding [IDA, ISO]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- aryl hydrocarbon receptor binding [ISO]
- bHLH transcription factor binding [IPI]
- core promoter binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISA]
- transcription factor binding [ISA]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
CSNK1E
Gene Ontology Biological Process
- cellular protein localization [IDA]
- circadian regulation of gene expression [IMP]
- circadian rhythm [TAS]
- endocytosis [IBA]
- negative regulation of Wnt signaling pathway [IGI]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of canonical Wnt signaling pathway [IGI]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [IMP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The de-ubiquitinylating enzyme, USP2, is associated with the circadian clockwork and regulates its sensitivity to light.
We have identified a novel component of the circadian clock that regulates its sensitivity to light at the evening light to dark transition. USP2 (Ubiquitin Specific Protease 2), which de-ubiquitinylates and stabilizes target proteins, is rhythmically expressed in multiple tissues including the SCN. We have developed a knockout model of USP2 and found that exposure to low irradiance light at ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID