CSNK1E
Gene Ontology Biological Process
- cellular protein localization [IDA]
- circadian regulation of gene expression [IMP]
- circadian rhythm [TAS]
- endocytosis [IBA]
- negative regulation of Wnt signaling pathway [IGI]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of canonical Wnt signaling pathway [IGI]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [IMP]
Gene Ontology Molecular Function
PER1
Gene Ontology Biological Process
- circadian regulation of gene expression [IDA, IMP, ISO]
- circadian regulation of translation [IMP]
- circadian rhythm [ISO, TAS]
- entrainment of circadian clock by photoperiod [IMP]
- histone H3 acetylation [IDA, ISO]
- histone H3 deacetylation [IMP]
- histone H4 acetylation [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of JNK cascade [ISO]
- negative regulation of glucocorticoid receptor signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- posttranscriptional regulation of gene expression [IMP]
- regulation of circadian rhythm [IMP]
- regulation of cytokine production involved in inflammatory response [ISO]
- regulation of hair cycle [ISO]
- regulation of p38MAPK cascade [ISO]
- regulation of sodium ion transport [IMP]
- response to cAMP [IDA]
Gene Ontology Molecular Function- E-box binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- chromatin DNA binding [IDA]
- kinase binding [IPI, ISO]
- protein binding [IPI]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- ubiquitin protein ligase binding [ISO]
- E-box binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- chromatin DNA binding [IDA]
- kinase binding [IPI, ISO]
- protein binding [IPI]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- ubiquitin protein ligase binding [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The de-ubiquitinylating enzyme, USP2, is associated with the circadian clockwork and regulates its sensitivity to light.
We have identified a novel component of the circadian clock that regulates its sensitivity to light at the evening light to dark transition. USP2 (Ubiquitin Specific Protease 2), which de-ubiquitinylates and stabilizes target proteins, is rhythmically expressed in multiple tissues including the SCN. We have developed a knockout model of USP2 and found that exposure to low irradiance light at ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PER1 CSNK1E | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | 676360 | |
| PER1 CSNK1E | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 676345 | |
| PER1 CSNK1E | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID