CSNK2A1
Gene Ontology Biological Process
- axon guidance [TAS]
- chaperone-mediated protein folding [TAS]
- mitotic cell cycle [TAS]
- mitotic spindle checkpoint [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of Wnt signaling pathway [IMP]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of protein catabolic process [IDA]
- protein phosphorylation [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RB1
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- cell cycle arrest [IMP]
- cell division [IMP]
- cell morphogenesis involved in neuron differentiation [IMP]
- digestive tract development [IMP]
- enucleate erythrocyte differentiation [IGI]
- glial cell apoptotic process [IMP]
- hepatocyte apoptotic process [IMP, ISO]
- maintenance of mitotic sister chromatid cohesion [ISO]
- myoblast differentiation [ISO]
- negative regulation of G1/S transition of mitotic cell cycle [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell cycle [IMP]
- negative regulation of cell proliferation [IGI, IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of mitotic cell cycle [IGI]
- negative regulation of protein kinase activity [ISO]
- negative regulation of smoothened signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neuron apoptotic process [IMP]
- neuron differentiation [IMP]
- neuron maturation [IMP]
- neuron projection development [IMP]
- positive regulation of macrophage differentiation [IGI]
- positive regulation of mitotic metaphase/anaphase transition [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- protein localization to chromosome, centromeric region [ISO]
- regulation of cell cycle [IMP]
- regulation of cohesin localization to chromatin [ISO]
- regulation of lipid kinase activity [ISO]
- regulation of mitotic cell cycle [ISO]
- sister chromatid biorientation [ISO]
- skeletal muscle cell differentiation [IMP]
- striated muscle cell differentiation [IGI]
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.
Fbxo7 is an unusual F-box protein because most of its interacting proteins are not substrates for ubiquitin-mediated degradation. Fbxo7 directly binds p27 and Cdk6, enhances the level of cyclin D-Cdk6 complexes, and its overexpression causes Cdk6-dependent transformation of immortalised fibroblasts. Here, we test the ability of Fbxo7 to transform haematopoietic pro-B (Ba/F3) cells which, unexpectedly, it was unable to do ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID