GRIK2
Gene Ontology Biological Process
- behavioral fear response [ISO]
- cellular calcium ion homeostasis [ISO]
- intracellular protein transport [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of synaptic transmission, glutamatergic [IDA, ISO]
- neuron apoptotic process [IMP]
- neuronal action potential [ISO]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of synaptic transmission [ISO]
- receptor clustering [IDA]
- regulation of JNK cascade [IMP]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of inhibitory postsynaptic membrane potential [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of membrane potential [ISO]
- regulation of short-term neuronal synaptic plasticity [ISO]
- regulation of synaptic transmission [ISO]
- signal transduction [IDA]
- synaptic transmission [IMP, ISO]
- synaptic transmission, glutamatergic [ISO]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [IDA]
- identical protein binding [IDA]
- ionotropic glutamate receptor activity [ISO, TAS]
- kainate selective glutamate receptor activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase binding [IPI]
- PDZ domain binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [IDA]
- identical protein binding [IDA]
- ionotropic glutamate receptor activity [ISO, TAS]
- kainate selective glutamate receptor activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- axon [IDA]
- cell [ISO]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- integral component of plasma membrane [IDA]
- intracellular [ISO]
- ionotropic glutamate receptor complex [IDA]
- kainate selective glutamate receptor complex [IBA, ISO]
- membrane [ISO]
- neuronal cell body [ISO]
- perikaryon [IDA]
- postsynaptic density [ISO]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IBA, ISO]
- synapse [IDA, ISO]
- terminal bouton [IDA]
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway.
Kainate receptors have been implicated in excitotoxic neuronal death induced by diseases such as epilepsy and stroke. Actinfilin, a synaptic member of the BTB-Kelch protein family, is known to bind to the actin cytoskeleton. However, little is understood about its function at the synapse. Here, we report that actinfilin is able to bind to GluR6, a kainate-type glutamate receptor subunit, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID