ADRBK1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO]
- cardiac muscle contraction [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway [IGI, IMP, ISO]
- follicle-stimulating hormone signaling pathway [ISO]
- heart development [IMP]
- negative regulation of G-protein coupled receptor protein signaling pathway [ISO]
- negative regulation of striated muscle contraction [ISO]
- negative regulation of the force of heart contraction by chemical signal [ISO]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of catecholamine secretion [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- receptor internalization [ISO]
- regulation of the force of heart contraction [IGI]
- response to organic cyclic compound [ISO]
- response to oxidative stress [ISO]
- tachykinin receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MDM2
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [ISO]
- establishment of protein localization [ISO]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell cycle arrest [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of protein processing [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- peptidyl-lysine modification [ISO]
- positive regulation of cell cycle [IGI]
- positive regulation of gene expression [ISO]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein export from nucleus [ISO]
- protein catabolic process [IDA]
- protein complex assembly [ISO]
- protein destabilization [ISO]
- protein localization to nucleus [ISO]
- protein ubiquitination [IDA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- regulation of protein catabolic process [ISO]
- traversing start control point of mitotic cell cycle [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2.
G protein-coupled receptor kinase 2 (GRK2) plays a fundamental role in the regulation of G protein-coupled receptors (GPCRs), and changes in GRK2 expression levels can have an important impact on cell functions. GRK2 is known to be degraded by the proteasome pathway. We have shown previously that β-arrestins participate in enhanced kinase turnover upon GPCR stimulation by facilitating GRK2 phosphorylation ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID