PPP1CA
Gene Ontology Biological Process
- branching morphogenesis of an epithelial tube [IMP]
- cellular process [TAS]
- circadian regulation of gene expression [IDA]
- dephosphorylation [ISS]
- entrainment of circadian clock by photoperiod [IMP]
- female meiotic division [TAS]
- glycogen metabolic process [TAS]
- lung development [IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- protein dephosphorylation [IDA, ISO, TAS]
- regulation of circadian rhythm [IDA, IMP, ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of glycogen catabolic process [ISO]
- regulation of translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- PTW/PP1 phosphatase complex [ISO]
- cytoplasm [IDA, ISO]
- dendritic spine [ISO]
- extracellular vesicular exosome [ISO]
- glycogen granule [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [IDA, ISO]
- nucleus [IDA, ISO]
- perikaryon [ISO]
- plasma membrane [ISO]
- protein phosphatase type 1 complex [ISO]
ATM
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- DNA damage induced protein phosphorylation [ISO]
- DNA repair [IDA, IMP]
- V(D)J recombination [IGI]
- brain development [IGI]
- cell cycle arrest [ISO]
- cellular response to DNA damage stimulus [ISO, TAS]
- cellular response to gamma radiation [ISO]
- double-strand break repair via homologous recombination [IBA]
- female gamete generation [IMP]
- heart development [IGI]
- histone mRNA catabolic process [ISO]
- histone phosphorylation [ISO]
- histone-serine phosphorylation [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IGI, IMP]
- lipoprotein catabolic process [IGI]
- mitotic spindle assembly checkpoint [ISO]
- negative regulation of B cell proliferation [ISO]
- neuron apoptotic process [IGI]
- oocyte development [IMP]
- peptidyl-serine phosphorylation [ISO]
- phosphatidylinositol phosphorylation [ISO]
- phosphatidylinositol-3-phosphate biosynthetic process [ISO]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of neuron apoptotic process [IGI]
- pre-B cell allelic exclusion [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of cell cycle [ISO]
- replicative senescence [ISO]
- response to hypoxia [ISO]
- response to ionizing radiation [IGI, ISO]
- signal transduction involved in mitotic G2 DNA damage checkpoint [ISO]
- somitogenesis [IGI]
Gene Ontology Molecular Function- 1-phosphatidylinositol-3-kinase activity [ISO]
- DNA-dependent protein kinase activity [ISO]
- histone serine kinase activity [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [IBA, ISO]
- protein kinase activity [IDA, TAS]
- protein serine/threonine kinase activity [ISO]
- 1-phosphatidylinositol-3-kinase activity [ISO]
- DNA-dependent protein kinase activity [ISO]
- histone serine kinase activity [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [IBA, ISO]
- protein kinase activity [IDA, TAS]
- protein serine/threonine kinase activity [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Protein phosphatase 1 (PP1) catalytic subunits typically combine with other proteins that modulate their activity, direct them to distinct substrates, or serve as substrates for PP1. More than 50 PP1-interacting proteins (PIPs) have been identified so far. Given there are approximately 10 000 phosphoproteins in mammals, many PIPs remain to be discovered. We have used arrays containing 100 carefully selected ... [more]
Throughput
- High Throughput
Curated By
- BioGRID