PPP1CA
Gene Ontology Biological Process
- branching morphogenesis of an epithelial tube [IMP]
- cellular process [TAS]
- circadian regulation of gene expression [IDA]
- dephosphorylation [ISS]
- entrainment of circadian clock by photoperiod [IMP]
- female meiotic division [TAS]
- glycogen metabolic process [TAS]
- lung development [IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- protein dephosphorylation [IDA, ISO, TAS]
- regulation of circadian rhythm [IDA, IMP, ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of glycogen catabolic process [ISO]
- regulation of translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- PTW/PP1 phosphatase complex [ISO]
- cytoplasm [IDA, ISO]
- dendritic spine [ISO]
- extracellular vesicular exosome [ISO]
- glycogen granule [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [IDA, ISO]
- nucleus [IDA, ISO]
- perikaryon [ISO]
- plasma membrane [ISO]
- protein phosphatase type 1 complex [ISO]
PCNA
Gene Ontology Biological Process
- base-excision repair, gap-filling [IDA]
- leading strand elongation [IBA]
- mismatch repair [IBA, ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of deoxyribonuclease activity [ISO]
- regulation of catalytic activity [IBA]
- response to lipid [ISO]
- translesion synthesis [IBA, ISO]
Gene Ontology Molecular Function- DNA polymerase binding [ISO]
- DNA polymerase processivity factor activity [IBA]
- MutLalpha complex binding [ISO]
- dinucleotide insertion or deletion binding [ISO]
- estrogen receptor binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- purine-specific mismatch base pair DNA N-glycosylase activity [ISO]
- receptor tyrosine kinase binding [ISO]
- transcription factor binding [IPI]
- DNA polymerase binding [ISO]
- DNA polymerase processivity factor activity [IBA]
- MutLalpha complex binding [ISO]
- dinucleotide insertion or deletion binding [ISO]
- estrogen receptor binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- purine-specific mismatch base pair DNA N-glycosylase activity [ISO]
- receptor tyrosine kinase binding [ISO]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Protein phosphatase 1 (PP1) catalytic subunits typically combine with other proteins that modulate their activity, direct them to distinct substrates, or serve as substrates for PP1. More than 50 PP1-interacting proteins (PIPs) have been identified so far. Given there are approximately 10 000 phosphoproteins in mammals, many PIPs remain to be discovered. We have used arrays containing 100 carefully selected ... [more]
Throughput
- High Throughput
Curated By
- BioGRID