PPP1CA
Gene Ontology Biological Process
- branching morphogenesis of an epithelial tube [IMP]
- cellular process [TAS]
- circadian regulation of gene expression [IDA]
- dephosphorylation [ISS]
- entrainment of circadian clock by photoperiod [IMP]
- female meiotic division [TAS]
- glycogen metabolic process [TAS]
- lung development [IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- protein dephosphorylation [IDA, ISO, TAS]
- regulation of circadian rhythm [IDA, IMP, ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of glycogen catabolic process [ISO]
- regulation of translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- PTW/PP1 phosphatase complex [ISO]
- cytoplasm [IDA, ISO]
- dendritic spine [ISO]
- extracellular vesicular exosome [ISO]
- glycogen granule [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [IDA, ISO]
- nucleus [IDA, ISO]
- perikaryon [ISO]
- plasma membrane [ISO]
- protein phosphatase type 1 complex [ISO]
PPP2R4
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- mitotic spindle organization in nucleus [IBA]
- negative regulation of phosphoprotein phosphatase activity [ISO]
- negative regulation of protein dephosphorylation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of catalytic activity [IBA]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- protein peptidyl-prolyl isomerization [IBA]
- regulation of phosphoprotein phosphatase activity [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- ATPase activity [ISO]
- peptidyl-prolyl cis-trans isomerase activity [IBA]
- protein homodimerization activity [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase type 2A regulator activity [IBA, ISO]
- protein tyrosine phosphatase activator activity [IBA, ISO]
- receptor binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- peptidyl-prolyl cis-trans isomerase activity [IBA]
- protein homodimerization activity [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase type 2A regulator activity [IBA, ISO]
- protein tyrosine phosphatase activator activity [IBA, ISO]
- receptor binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Protein phosphatase 1 (PP1) catalytic subunits typically combine with other proteins that modulate their activity, direct them to distinct substrates, or serve as substrates for PP1. More than 50 PP1-interacting proteins (PIPs) have been identified so far. Given there are approximately 10 000 phosphoproteins in mammals, many PIPs remain to be discovered. We have used arrays containing 100 carefully selected ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PPP2R4 PPP1CA | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.721 | BioGRID | 2664530 |
Curated By
- BioGRID