PPP1CA
Gene Ontology Biological Process
- branching morphogenesis of an epithelial tube [IMP]
- cellular process [TAS]
- circadian regulation of gene expression [IDA]
- dephosphorylation [ISS]
- entrainment of circadian clock by photoperiod [IMP]
- female meiotic division [TAS]
- glycogen metabolic process [TAS]
- lung development [IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- protein dephosphorylation [IDA, ISO, TAS]
- regulation of circadian rhythm [IDA, IMP, ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of glycogen catabolic process [ISO]
- regulation of translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- PTW/PP1 phosphatase complex [ISO]
- cytoplasm [IDA, ISO]
- dendritic spine [ISO]
- extracellular vesicular exosome [ISO]
- glycogen granule [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [IDA, ISO]
- nucleus [IDA, ISO]
- perikaryon [ISO]
- plasma membrane [ISO]
- protein phosphatase type 1 complex [ISO]
ID2
Gene Ontology Biological Process
- Peyer's patch development [IGI]
- adipose tissue development [IMP]
- bundle of His development [IMP]
- cell development [IGI]
- cell maturation [IMP]
- cellular response to lithium ion [IDA]
- cellular senescence [IMP]
- circadian regulation of gene expression [IMP]
- embryonic digestive tract morphogenesis [IDA]
- entrainment of circadian clock [IMP]
- entrainment of circadian clock by photoperiod [IMP]
- enucleate erythrocyte differentiation [IGI]
- epithelial cell differentiation involved in mammary gland alveolus development [IMP]
- heart development [IGI]
- leukocyte differentiation [IMP]
- locomotor rhythm [IMP]
- lymph node development [TAS]
- mammary gland alveolus development [IMP]
- mammary gland epithelial cell proliferation [IMP]
- membranous septum morphogenesis [IMP]
- metanephros development [IMP]
- natural killer cell differentiation [IGI, IMP]
- negative regulation of B cell differentiation [IMP]
- negative regulation of DNA binding [IDA]
- negative regulation of gene expression [IMP, ISO]
- negative regulation of neural precursor cell proliferation [IMP]
- negative regulation of neuron differentiation [IMP]
- negative regulation of oligodendrocyte differentiation [IMP]
- negative regulation of osteoblast differentiation [IGI]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- neuron fate commitment [IMP]
- olfactory bulb development [IMP]
- oligodendrocyte development [IMP]
- positive regulation of astrocyte differentiation [IMP]
- positive regulation of blood pressure [IMP]
- positive regulation of cell cycle [ISO]
- positive regulation of cell cycle arrest [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of macrophage differentiation [IGI]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of G1/S transition of mitotic cell cycle [ISO]
- regulation of circadian rhythm [IMP]
- regulation of lipid metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Protein phosphatase 1 (PP1) catalytic subunits typically combine with other proteins that modulate their activity, direct them to distinct substrates, or serve as substrates for PP1. More than 50 PP1-interacting proteins (PIPs) have been identified so far. Given there are approximately 10 000 phosphoproteins in mammals, many PIPs remain to be discovered. We have used arrays containing 100 carefully selected ... [more]
Throughput
- High Throughput
Curated By
- BioGRID