PPP1CC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BCL2L1
Gene Ontology Biological Process
- apoptotic process in bone marrow [IMP]
- cell proliferation [IDA]
- cellular process regulating host cell cycle in response to virus [IMP]
- cellular response to alkaloid [IDA]
- cellular response to amino acid stimulus [IMP]
- cellular response to gamma radiation [IMP]
- cytokinesis [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- fertilization [IGI]
- germ cell development [IGI, IMP]
- growth [IMP]
- hepatocyte apoptotic process [IMP]
- in utero embryonic development [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- male gonad development [IMP]
- mitochondrion morphogenesis [IGI]
- mitotic cell cycle checkpoint [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IDA, IGI, IMP, ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of establishment of protein localization to plasma membrane [ISO]
- negative regulation of execution phase of apoptosis [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of neuron apoptotic process [IDA, IGI, IMP]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- neuron apoptotic process [IGI, IMP]
- ovarian follicle development [IGI, IMP, ISO]
- positive regulation of apoptotic process [IDA]
- positive regulation of cell proliferation [IDA]
- regulation of apoptotic process [ISO]
- regulation of mitochondrial membrane permeability [ISO]
- regulation of mitochondrial membrane potential [ISO]
- release of cytochrome c from mitochondria [IGI, ISO]
- response to cycloheximide [IDA]
- response to cytokine [ISO]
- response to ischemia [ISO]
- response to radiation [IMP]
- response to virus [IDA]
- spermatogenesis [IGI]
- suppression by virus of host apoptotic process [ISO]
Gene Ontology Molecular Function- BH domain binding [ISO]
- BH3 domain binding [ISO]
- MDM2/MDM4 family protein binding [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA]
- protein kinase binding [ISO]
- BH domain binding [ISO]
- BH3 domain binding [ISO]
- MDM2/MDM4 family protein binding [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA]
- protein kinase binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Protein phosphatase 1 (PP1) catalytic subunits typically combine with other proteins that modulate their activity, direct them to distinct substrates, or serve as substrates for PP1. More than 50 PP1-interacting proteins (PIPs) have been identified so far. Given there are approximately 10 000 phosphoproteins in mammals, many PIPs remain to be discovered. We have used arrays containing 100 carefully selected ... [more]
Throughput
- High Throughput
Curated By
- BioGRID