PPP1CC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDK1
Gene Ontology Biological Process
- cell aging [ISO]
- chromosome condensation [ISO]
- histone phosphorylation [ISO]
- mitotic G2 DNA damage checkpoint [IDA]
- negative regulation of apoptotic process [ISO]
- organ regeneration [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of cardiac muscle cell proliferation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- protein complex assembly [ISO]
- protein localization to kinetochore [ISO]
- protein phosphorylation [IDA]
- response to ethanol [ISO]
- response to organonitrogen compound [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Protein phosphatase 1 (PP1) catalytic subunits typically combine with other proteins that modulate their activity, direct them to distinct substrates, or serve as substrates for PP1. More than 50 PP1-interacting proteins (PIPs) have been identified so far. Given there are approximately 10 000 phosphoproteins in mammals, many PIPs remain to be discovered. We have used arrays containing 100 carefully selected ... [more]
Throughput
- High Throughput
Curated By
- BioGRID