PPP1CC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CCNB1
Gene Ontology Biological Process
- histone H3-S10 phosphorylation involved in chromosome condensation [IDA]
- histone phosphorylation [ISO]
- in utero embryonic development [IMP]
- mitotic metaphase plate congression [ISO]
- mitotic spindle stabilization [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of protein phosphorylation [ISO]
- oocyte maturation [ISO]
- positive regulation of attachment of spindle microtubules to kinetochore [ISO]
- positive regulation of cardiac muscle cell proliferation [ISO]
- positive regulation of cell cycle [IDA]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of histone phosphorylation [ISO]
- positive regulation of mRNA 3'-end processing [ISO]
- positive regulation of mitotic cell cycle [ISO]
- protein complex assembly [ISO]
- protein phosphorylation [IDA]
- regulation of chromosome condensation [ISO]
- regulation of mitotic cell cycle spindle assembly checkpoint [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Protein phosphatase 1 (PP1) catalytic subunits typically combine with other proteins that modulate their activity, direct them to distinct substrates, or serve as substrates for PP1. More than 50 PP1-interacting proteins (PIPs) have been identified so far. Given there are approximately 10 000 phosphoproteins in mammals, many PIPs remain to be discovered. We have used arrays containing 100 carefully selected ... [more]
Throughput
- High Throughput
Curated By
- BioGRID