PPP1CC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CCND1
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA, ISO]
- Leydig cell differentiation [ISO]
- Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway [IMP]
- cellular response to DNA damage stimulus [ISO]
- cellular response to organic substance [IDA]
- endoplasmic reticulum unfolded protein response [IDA]
- fat cell differentiation [IDA]
- lactation [IGI, IMP]
- mammary gland alveolus development [IGI, IMP]
- mammary gland epithelial cell proliferation [IGI]
- mitotic G1 DNA damage checkpoint [ISO]
- negative regulation of Wnt signaling pathway [IMP]
- negative regulation of cell cycle arrest [ISO]
- negative regulation of epithelial cell differentiation [IGI]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of G2/M transition of mitotic cell cycle [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- positive regulation of mammary gland epithelial cell proliferation [IGI]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [IDA]
- re-entry into mitotic cell cycle [IDA]
- regulation of G1/S transition of mitotic cell cycle [IGI]
- regulation of cell cycle [IDA]
- regulation of protein kinase activity [IDA]
- response to UV-A [ISO]
- response to organonitrogen compound [ISO]
Gene Ontology Molecular Function- cyclin-dependent protein serine/threonine kinase regulator activity [IDA]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- kinase activity [IDA]
- proline-rich region binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [IPI, ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [ISO]
- cyclin-dependent protein serine/threonine kinase regulator activity [IDA]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- kinase activity [IDA]
- proline-rich region binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [IPI, ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Protein phosphatase 1 (PP1) catalytic subunits typically combine with other proteins that modulate their activity, direct them to distinct substrates, or serve as substrates for PP1. More than 50 PP1-interacting proteins (PIPs) have been identified so far. Given there are approximately 10 000 phosphoproteins in mammals, many PIPs remain to be discovered. We have used arrays containing 100 carefully selected ... [more]
Throughput
- High Throughput
Curated By
- BioGRID