NEURL1B
DLL4
Gene Ontology Biological Process
- Notch signaling involved in heart development [IMP]
- angiogenesis [IMP]
- blood vessel lumenization [IMP]
- blood vessel remodeling [IMP]
- cardiac atrium morphogenesis [IMP]
- cardiac ventricle morphogenesis [IMP]
- cellular response to fibroblast growth factor stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- dorsal aorta morphogenesis [IMP]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [ISO]
- negative regulation of cell migration involved in sprouting angiogenesis [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of endothelial cell migration [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- patterning of blood vessels [IMP]
- pericardium morphogenesis [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of neural precursor cell proliferation [IMP]
- regulation of neural retina development [IMP]
- regulation of neurogenesis [IMP]
- ventral spinal cord interneuron fate commitment [ISO]
- ventricular trabecula myocardium morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Neuralized-2: expression in human and rodents and interaction with Delta-like ligands.
Delta-Notch signaling is a universal cell-cell communication pathway crucial for numerous developmental and physiological processes. Several proteins interact with and regulate the Notch pathway, including the E3 ubiquitin ligase Neuralized (Neur) that influences the stability and activity of Notch ligands. In mammals there are two homologs of Neur, Neur1 and Neur2, that both can interact with Notch ligands Delta-like1 and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NEURL1B DLL4 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | - |
Curated By
- BioGRID