NEURL1A
Gene Ontology Biological Process
- cellular response to amino acid stimulus [IDA]
- lactation [IMP]
- negative regulation of Notch signaling pathway [ISO]
- negative regulation of cell proliferation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of dendritic spine development [IDA]
- positive regulation of epidermal growth factor-activated receptor activity [IMP]
- positive regulation of filopodium assembly [IDA]
- positive regulation of long-term neuronal synaptic plasticity [IDA]
- positive regulation of synapse maturation [IDA]
- protein monoubiquitination [IDA]
- regulation of translation [IDA]
- sperm axoneme assembly [IMP]
- sperm motility [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DLL1
Gene Ontology Biological Process
- Notch signaling involved in heart development [IC]
- Notch signaling pathway [ISO, TAS]
- auditory receptor cell differentiation [NAS]
- auditory receptor cell fate commitment [NAS]
- cell-cell signaling [IDA]
- compartment pattern specification [IMP]
- determination of left/right symmetry [IMP]
- heart looping [IMP]
- in utero embryonic development [NAS]
- inner ear development [IMP]
- inner ear morphogenesis [NAS]
- left/right axis specification [IMP]
- negative regulation of auditory receptor cell differentiation [IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of interleukin-10 production [ISO]
- negative regulation of myeloid cell differentiation [IDA]
- negative regulation of neuron differentiation [IMP]
- nervous system development [NAS]
- odontogenesis of dentin-containing tooth [NAS]
- organ morphogenesis [NAS]
- positive regulation of Notch signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of neurogenesis [IMP]
- somite specification [IMP]
- somitogenesis [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Neuralized-2: expression in human and rodents and interaction with Delta-like ligands.
Delta-Notch signaling is a universal cell-cell communication pathway crucial for numerous developmental and physiological processes. Several proteins interact with and regulate the Notch pathway, including the E3 ubiquitin ligase Neuralized (Neur) that influences the stability and activity of Notch ligands. In mammals there are two homologs of Neur, Neur1 and Neur2, that both can interact with Notch ligands Delta-like1 and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NEURL1A DLL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID