BAIT
NOTCH1
9930111A19Rik, Mis6, N1, Tan1, lin-12, RP23-306D20.12-001
notch 1
GO Process (135)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- Notch signaling involved in heart development [IGI, IMP, ISO]
- Notch signaling pathway [IC, IDA, IMP, ISO]
- Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [IMP]
- anagen [IMP]
- aortic valve morphogenesis [ISO]
- apoptotic process involved in embryonic digit morphogenesis [IMP]
- arterial endothelial cell differentiation [IMP]
- astrocyte differentiation [ISO]
- atrioventricular node development [IMP]
- atrioventricular valve morphogenesis [IMP]
- auditory receptor cell fate commitment [IMP]
- axonogenesis [IDA, IMP]
- branching morphogenesis of an epithelial tube [IMP]
- cardiac atrium morphogenesis [IMP]
- cardiac chamber formation [IMP]
- cardiac epithelial to mesenchymal transition [IMP]
- cardiac left ventricle morphogenesis [IMP]
- cardiac muscle cell proliferation [IMP]
- cardiac muscle tissue morphogenesis [IMP]
- cardiac right atrium morphogenesis [IMP]
- cardiac right ventricle formation [IMP]
- cardiac septum morphogenesis [IMP]
- cardiac vascular smooth muscle cell development [IMP]
- cardiac ventricle morphogenesis [IMP]
- cell differentiation [IMP]
- cell fate commitment [IMP]
- cell fate specification [IMP]
- cell migration involved in endocardial cushion formation [IMP]
- cellular response to follicle-stimulating hormone stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- compartment pattern specification [IMP]
- coronary artery morphogenesis [IMP]
- coronary vein morphogenesis [IMP]
- determination of left/right symmetry [IMP]
- embryonic hindlimb morphogenesis [IMP]
- embryonic limb morphogenesis [IGI]
- endocardial cell differentiation [IMP]
- endocardial cushion morphogenesis [IMP]
- endocardium development [IMP]
- endocardium morphogenesis [IMP]
- endoderm development [IMP]
- epidermis development [IGI]
- epithelial to mesenchymal transition [IMP]
- epithelial to mesenchymal transition involved in endocardial cushion formation [IMP]
- forebrain development [IGI, IMP]
- foregut morphogenesis [IMP]
- glial cell differentiation [IMP]
- growth involved in heart morphogenesis [IMP]
- hair follicle morphogenesis [IMP]
- heart development [IMP, ISO]
- heart looping [IGI]
- heart trabecula morphogenesis [IMP]
- humoral immune response [IGI]
- in utero embryonic development [IMP]
- inflammatory response to antigenic stimulus [IGI]
- interleukin-4 secretion [IGI]
- keratinocyte differentiation [IMP]
- left/right axis specification [IGI]
- liver development [IMP]
- lung development [IMP]
- mesenchymal cell development [IMP]
- mitral valve formation [ISO]
- negative regulation of BMP signaling pathway [IMP]
- negative regulation of anoikis [ISO]
- negative regulation of calcium ion-dependent exocytosis [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of catalytic activity [IDA]
- negative regulation of cell death [IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell migration involved in sprouting angiogenesis [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cell-substrate adhesion [ISO]
- negative regulation of endothelial cell chemotaxis [ISO]
- negative regulation of glial cell proliferation [IDA]
- negative regulation of myoblast differentiation [ISO]
- negative regulation of myotube differentiation [IDA]
- negative regulation of neurogenesis [IDA]
- negative regulation of neuron differentiation [IGI, IMP, ISO]
- negative regulation of oligodendrocyte differentiation [IDA]
- negative regulation of ossification [IMP]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of photoreceptor cell differentiation [IMP]
- negative regulation of pro-B cell differentiation [IMP]
- negative regulation of stem cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- neural tube development [IMP]
- neuron differentiation [IMP]
- neuron fate commitment [IGI]
- osteoblast fate commitment [NAS]
- pericardium morphogenesis [IMP]
- positive regulation of BMP signaling pathway [IDA]
- positive regulation of JAK-STAT cascade [IDA]
- positive regulation of apoptotic process [IDA, IGI]
- positive regulation of astrocyte differentiation [IDA]
- positive regulation of cardiac muscle cell proliferation [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of endothelial cell differentiation [ISO]
- positive regulation of ephrin receptor signaling pathway [IC]
- positive regulation of epithelial cell proliferation [IGI]
- positive regulation of epithelial to mesenchymal transition [IMP, ISO]
- positive regulation of glial cell differentiation [ISO]
- positive regulation of keratinocyte differentiation [IDA, IGI]
- positive regulation of neuroblast proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA]
- positive regulation of transcription of Notch receptor target [IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- prostate gland epithelium morphogenesis [IMP]
- pulmonary valve morphogenesis [ISO]
- regulation of cardioblast proliferation [ISO]
- regulation of cell adhesion involved in heart morphogenesis [IC]
- regulation of cell migration [IMP]
- regulation of cell proliferation [ISO]
- regulation of epithelial cell proliferation [IMP]
- regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- regulation of extracellular matrix assembly [IMP]
- regulation of gene expression [IMP]
- regulation of neurogenesis [IMP]
- regulation of somitogenesis [IMP]
- regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [IMP]
- response to muramyl dipeptide [IDA]
- secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [IMP]
- skeletal muscle cell differentiation [IMP]
- somatic stem cell division [IDA, IGI]
- spermatogenesis [ISO]
- sprouting angiogenesis [IMP]
- transcription from RNA polymerase II promoter [IDA]
- tube formation [ISO]
- vasculogenesis involved in coronary vascular morphogenesis [IMP]
- venous endothelial cell differentiation [IMP]
- ventricular septum morphogenesis [ISO]
- ventricular trabecula myocardium morphogenesis [IMP]
Gene Ontology Molecular Function- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin DNA binding [IDA]
- chromatin binding [IDA]
- core promoter binding [IDA]
- enzyme binding [IPI]
- enzyme inhibitor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin DNA binding [IDA]
- chromatin binding [IDA]
- core promoter binding [IDA]
- enzyme binding [IPI]
- enzyme inhibitor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
RBPJ
AI843960, CBF1, Igkjrb, Igkrsbp, RBP-J, RBP-J kappa, RBPjk, Rbpsuh
recombination signal binding protein for immunoglobulin kappa J region
GO Process (66)
GO Function (11)
GO Component (8)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- Clara cell differentiation [IMP]
- Notch signaling pathway [IMP, ISO]
- Notch signaling pathway involved in arterial endothelial cell fate commitment [IC]
- angiogenesis [IMP]
- arterial endothelial cell fate commitment [IMP]
- atrioventricular canal development [IMP]
- auditory receptor cell fate commitment [IMP]
- blood vessel endothelial cell fate specification [IGI]
- blood vessel lumenization [IMP]
- blood vessel remodeling [IMP]
- cardiac left ventricle morphogenesis [IMP]
- cell fate commitment [IMP]
- defense response to bacterium [IMP]
- determination of heart left/right asymmetry [TAS]
- dorsal aorta morphogenesis [IMP]
- endocardium development [IMP]
- endocardium morphogenesis [IMP]
- epidermal cell fate specification [IMP]
- epithelial to mesenchymal transition [IMP]
- epithelial to mesenchymal transition involved in endocardial cushion formation [IMP]
- hair follicle maturation [IMP]
- heart development [IMP]
- heart looping [TAS]
- hemopoiesis [IMP]
- humoral immune response [IMP]
- inflammatory response to antigenic stimulus [IMP]
- interleukin-4 secretion [IMP]
- keratinocyte differentiation [IMP]
- labyrinthine layer blood vessel development [IMP]
- myeloid dendritic cell differentiation [IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of neuron projection development [ISO]
- negative regulation of ossification [IMP]
- negative regulation of smooth muscle cell apoptotic process [ISO]
- negative regulation of smooth muscle cell migration [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neuron differentiation [IMP]
- outflow tract morphogenesis [IMP]
- pituitary gland development [IMP]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of ERBB signaling pathway [IMP]
- positive regulation of Notch signaling pathway involved in heart induction [TAS]
- positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [IMP]
- positive regulation of cardiac muscle cell proliferation [IMP]
- positive regulation of cell proliferation [IGI]
- positive regulation of cell proliferation involved in heart morphogenesis [IMP]
- positive regulation of ephrin receptor signaling pathway [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription of Notch receptor target [IGI, ISO]
- positive regulation of transcription, DNA-templated [ISA, ISO]
- regulation of cell adhesion involved in heart morphogenesis [IC]
- regulation of gene expression [IMP]
- regulation of timing of cell differentiation [IMP]
- regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [IMP]
- sebaceous gland development [IMP]
- secondary heart field specification [IGI, IMP]
- somatic stem cell maintenance [IMP]
- somitogenesis [IMP, TAS]
- transcription from RNA polymerase II promoter [IDA]
- ventricular trabecula myocardium morphogenesis [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [ISO]
- sequence-specific DNA binding [IDA]
- transcription factor binding [IPI]
- DNA binding [IDA, ISA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [ISO]
- sequence-specific DNA binding [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase.
Integrin-linked kinase (ILK) is a scaffold and protein kinase that acts as a pivotal effector in integrin signaling for various cellular functions. In this study, we found that ILK remarkably reduced the protein stability of Notch1 through Fbw7. The kinase activity of ILK was essential for the inhibition of Notch1 signaling. Notably, the protein level and transcriptional activity of the ... [more]
Mol. Cell. Biol. Aug. 01, 2007; 27(15);5565-74 [Pubmed: 17526737]
Throughput
- Low Throughput
Additional Notes
- interaction lost in the presence of ILK
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RBPJ NOTCH1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| RBPJ NOTCH1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID