Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease.

Kajiwara Y, Franciosi S, Takahashi N, Krug L, Schmeidler J, Taddei K, Haroutunian V, Fried U, Ehrlich M, Martins RN, Gandy S, Buxbaum JD

The low-density lipoprotein receptor related protein 1 (LRP1) has been implicated in Alzheimer's disease (AD) but its signalling has not been fully evaluated. There is good evidence that the cytoplasmic domain of LRP1 is involved in protein-protein interactions, important in the cell biology of LRP1.We carried out three yeast two-hybrid screens to identify proteins that interact with the cytoplasmic domain ... [more]

Mol Neurodegener Mar. 09, 2010; 5(0);1 [Pubmed: 20205790]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

LRP1

Gene Ontology Biological Process

Gene Ontology Molecular Function

apolipoprotein binding [IDA, IPI]calcium ion binding [ISS]lipoprotein particle receptor binding [IC]lipoprotein transporter activity [NAS]poly(A) RNA binding [IDA]protein binding [IPI]protein complex binding [IDA]receptor activity [TAS]

Gene Ontology Cellular Component

CC2D1A