PRPS1
Gene Ontology Biological Process
- 5-phosphoribose 1-diphosphate biosynthetic process [IDA]
- AMP biosynthetic process [IDA]
- hypoxanthine biosynthetic process [ISO]
- nervous system development [ISO]
- nucleotide biosynthetic process [IDA]
- organ regeneration [IEP]
- purine nucleobase metabolic process [ISO]
- purine nucleotide biosynthetic process [ISO]
- ribose phosphate metabolic process [IDA]
- urate biosynthetic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
XIAP
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [ISO]
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process [IBA, ISO]
- negative regulation of apoptotic process [IMP, ISO, TAS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of neuron apoptotic process [IDA, IMP]
- neuron apoptotic process [ISO]
- positive regulation of canonical Wnt signaling pathway [IBA, ISO]
- positive regulation of protein linear polyubiquitination [ISO]
- positive regulation of protein ubiquitination [ISO]
- protein ubiquitination [IBA, ISO]
- spindle assembly involved in mitosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Parkin Promotes Degradation of the Mitochondrial Pro-Apoptotic ARTS Protein.
Parkinson's disease (PD) is associated with excessive cell death causing selective loss of dopaminergic neurons. Dysfunction of the Ubiquitin Proteasome System (UPS) is associated with the pathophysiology of PD. Mutations in Parkin which impair its E3-ligase activity play a major role in the pathogenesis of inherited PD. ARTS (Sept4_i2) is a mitochondrial protein, which initiates caspase activation upstream of cytochrome ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID