SMAD7
Gene Ontology Biological Process
- adherens junction assembly [ISO]
- artery morphogenesis [ISO]
- cellular protein complex localization [ISO]
- cellular response to transforming growth factor beta stimulus [ISO]
- intracellular signal transduction [IDA]
- negative regulation of BMP signaling pathway [ISO]
- negative regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of peptidyl-threonine phosphorylation [ISO]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription by competitive promoter binding [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IEP]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- negative regulation of ubiquitin-protein transferase activity [ISO]
- pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of cell-cell adhesion [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- protein stabilization [ISO]
- regulation of activin receptor signaling pathway [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of transforming growth factor beta receptor signaling pathway [IDA]
- response to laminar fluid shear stress [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
- ventricular cardiac muscle tissue morphogenesis [ISO]
- ventricular septum morphogenesis [ISO]
Gene Ontology Molecular Function- I-SMAD binding [ISO]
- activin binding [ISO]
- beta-catenin binding [ISO]
- collagen binding [ISO]
- protein binding [IPI]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- I-SMAD binding [ISO]
- activin binding [ISO]
- beta-catenin binding [ISO]
- collagen binding [ISO]
- protein binding [IPI]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [IPI, ISO]
Gene Ontology Cellular Component
SMURF2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Effects of Arkadia on airway remodeling through enhancing TGF-beta signaling in allergic rats.
Upregulation of transforming growth factor-beta (TGF-beta) signaling is interrelated with the development of airway remodeling. In this study, we examined the role of two E3 ubiquitin ligases, Arkadia and Smurf2, which are critically required for TGF-beta signaling in airway remodeling. Rats were immunized with ovalbumin (OVA) and then challenged with an OVA aerosol. In in vitro experiments, normal human bronchial ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SMAD7 SMURF2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID