SKI
Gene Ontology Biological Process
- SMAD protein signal transduction [ISO]
- anterior/posterior axis specification [ISO]
- bone morphogenesis [ISO]
- camera-type eye development [ISO]
- camera-type eye morphogenesis [ISO]
- embryonic limb morphogenesis [ISO]
- face morphogenesis [ISO]
- lens morphogenesis in camera-type eye [ISO]
- myelination in peripheral nervous system [ISO]
- myotube differentiation [ISO]
- negative regulation of BMP signaling pathway [ISO]
- negative regulation of Schwann cell proliferation [ISO]
- negative regulation of activin receptor signaling pathway [ISO]
- negative regulation of catalytic activity [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of fibroblast proliferation [ISO]
- negative regulation of histone deacetylation [ISO]
- negative regulation of osteoblast differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [IBA, ISO]
- neural tube closure [ISO]
- nose morphogenesis [ISO]
- olfactory bulb development [ISO]
- palate development [ISO]
- positive regulation of DNA binding [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein homotrimerization [ISO]
- regulation of apoptotic process [IBA]
- retina development in camera-type eye [ISO]
- skeletal muscle fiber development [ISO]
- somatic stem cell maintenance [ISO]
Gene Ontology Molecular Function- SMAD binding [IBA, ISO]
- chromatin binding [ISO]
- histone deacetylase inhibitor activity [ISO]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- repressing transcription factor binding [ISO]
- transcription corepressor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- zinc ion binding [ISO]
- SMAD binding [IBA, ISO]
- chromatin binding [ISO]
- histone deacetylase inhibitor activity [ISO]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- repressing transcription factor binding [ISO]
- transcription corepressor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
RNF111
Gene Ontology Biological Process
- pattern specification process [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISO]
- protein polyubiquitination [ISO]
- ubiquitin-dependent SMAD protein catabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Effects of Arkadia on airway remodeling through enhancing TGF-beta signaling in allergic rats.
Upregulation of transforming growth factor-beta (TGF-beta) signaling is interrelated with the development of airway remodeling. In this study, we examined the role of two E3 ubiquitin ligases, Arkadia and Smurf2, which are critically required for TGF-beta signaling in airway remodeling. Rats were immunized with ovalbumin (OVA) and then challenged with an OVA aerosol. In in vitro experiments, normal human bronchial ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID