CNR1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [ISO, ISS]
- aging [IMP]
- axonal fasciculation [ISO]
- cannabinoid signaling pathway [IMP, ISO]
- glucose homeostasis [ISO]
- learning or memory [IMP]
- maternal process involved in female pregnancy [IEP]
- memory [IDA]
- negative regulation of action potential [IMP]
- negative regulation of blood pressure [IMP]
- negative regulation of dopamine secretion [IMP]
- negative regulation of fatty acid beta-oxidation [IMP]
- negative regulation of ion transport [IDA]
- negative regulation of mast cell activation [IDA]
- negative regulation of nitric-oxide synthase activity [IMP]
- positive regulation of acute inflammatory response to antigenic stimulus [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of blood pressure [IMP]
- positive regulation of fever generation [IMP]
- positive regulation of neuron projection development [IDA]
- regulation of feeding behavior [IMP]
- regulation of insulin secretion [IMP]
- regulation of lipid metabolic process [IMP]
- regulation of penile erection [IMP]
- regulation of synaptic transmission, GABAergic [IMP]
- regulation of synaptic transmission, glutamatergic [IMP]
- response to cocaine [IMP]
- response to ethanol [IMP]
- response to lipopolysaccharide [IMP]
- response to morphine [IMP]
- response to nicotine [IMP]
- response to nutrient [IEP]
- sensory perception of pain [IMP]
- spermatogenesis [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SUMO1
Gene Ontology Biological Process
- PML body organization [ISO]
- negative regulation of DNA binding [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- palate development [ISO, ISS]
- positive regulation of calcium-transporting ATPase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein complex assembly [ISO]
- protein localization to nuclear pore [ISO]
- protein sumoylation [ISO, ISS]
- regulation of calcium ion transmembrane transport [ISO]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of protein stability [ISO]
- regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Delta(9)-tetrahydrocannabinol regulates the p53 post-translational modifiers Murine double minute 2 and the Small Ubiquitin MOdifier protein in the rat brain.
The phytocannabinoid Delta(9)-Tetrahydrocannabinol (Delta(9)-THC), the main psychoactive cannabinoid in cannabis, activates a number of signalling cascades including p53. This study examines the role of Delta(9)-THC in regulating the p53 post-translational modifier proteins, Murine double minute (Mdm2) and Small Ubquitin-like MOdifier protein 1 (SUMO-1) in cortical neurons. Delta(9)-THC increased both Mdm2 and SUMO-1 protein expression and induced the deSUMOylation of p53 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID