Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 via a PXVXL binding motif.

Xu X, Lee YJ, Holm JB, Terry MD, Oswald RE, Horne WA

The β subunits of voltage-gated Ca(2+) channels are best known for their roles in regulating surface expression and gating of voltage-gated Ca(2+) channel α(1) subunits. Recent evidence, however, indicates that these proteins have a variety of Ca(2+) channel-independent functions. For example, on the molecular level, they regulate gene expression, and on the whole animal level, they regulate early cell movements ... [more]

J. Biol. Chem. Mar. 18, 2011; 286(11);9677-87 [Pubmed: 21220418]

Throughput

  • Low Throughput

Additional Notes

  • figure 4. CSD domain of HP1g. also measured by ITC.
  • figure 5. NMR.

Curated By

  • BioGRID