BAIT
INPP5D
SHIP, SHIP-1, SHIP1, SIP-145, p150Ship, s-SHIP
inositol polyphosphate-5-phosphatase D
GO Process (19)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- dephosphorylation [IDA]
- determination of adult lifespan [IMP]
- immunoglobulin mediated immune response [IMP]
- intracellular signal transduction [IMP]
- negative regulation of B cell activation [IMP]
- negative regulation of B cell proliferation [IMP]
- negative regulation of bone resorption [IMP]
- negative regulation of cell proliferation [IDA]
- negative regulation of granulocyte differentiation [IMP]
- negative regulation of immune response [IMP]
- negative regulation of interleukin-6 biosynthetic process [IMP]
- negative regulation of monocyte differentiation [IMP]
- negative regulation of neutrophil differentiation [IMP]
- negative regulation of osteoclast differentiation [IMP]
- negative regulation of signal transduction [IMP]
- positive regulation of B cell differentiation [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of lymphocyte differentiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CTNND1
AA409437, AU019353, Catns, Ctnnd, P120, mKIAA0384
catenin (cadherin associated protein), delta 1
GO Process (7)
GO Function (7)
GO Component (15)
Gene Ontology Biological Process
- cell adhesion [IMP]
- epithelial cell differentiation involved in salivary gland development [IMP]
- keratinocyte differentiation [IMP]
- morphogenesis of a polarized epithelium [IMP]
- negative regulation of canonical Wnt signaling pathway [ISO]
- salivary gland morphogenesis [IMP]
- single organismal cell-cell adhesion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell-cell adherens junction [IDA]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dendritic spine [ISO]
- extracellular vesicular exosome [ISO]
- growth cone [ISO]
- lamellipodium [IDA, ISO]
- membrane [IDA]
- midbody [ISO]
- nucleus [ISO]
- plasma membrane [IMP, ISO]
- synapse [ISO]
- tight junction [IDA]
- zonula adherens [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts.
c-Src plays an important role in bone resorption by osteoclasts. Here, we show using wild-type and ship(-/-) osteoclasts that Src homology 2 (SH2)-containing 5'-inositol phosphatase (SHIP) appeared to negatively regulate bone resorption activated by c-Src. SHIP was found to localize to podosomes under the influence of c-Src, and the presence of either the amino-terminal region comprising the SH2 domain or ... [more]
Endocrinology Jul. 01, 2006; 147(7);3307-17 [Pubmed: 16601135]
Throughput
- Low Throughput
Curated By
- BioGRID