PRKCE
Gene Ontology Biological Process
- TRAM-dependent toll-like receptor 4 signaling pathway [ISO, ISS]
- cellular response to ethanol [ISO]
- cellular response to hypoxia [ISO]
- intracellular signal transduction [IDA]
- lipopolysaccharide-mediated signaling pathway [ISO, ISS]
- locomotory exploration behavior [ISO]
- macrophage activation involved in immune response [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of mitochondrial calcium ion concentration [IMP]
- negative regulation of mitochondrial membrane potential [IMP]
- negative regulation of release of sequestered calcium ion into cytosol [IMP]
- peptidyl-serine phosphorylation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of actin filament polymerization [ISO, ISS]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of cellular glucuronidation [ISO]
- positive regulation of cytokinesis [ISO, ISS]
- positive regulation of epithelial cell migration [ISO, ISS]
- positive regulation of fibroblast migration [ISO, ISS]
- positive regulation of insulin secretion [ISO]
- positive regulation of lipid catabolic process [ISO]
- positive regulation of mucus secretion [ISO]
- positive regulation of receptor activity [ISO]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of wound healing [ISO, ISS]
- protein phosphorylation [ISO]
- regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- regulation of lipid metabolic process [ISO]
- regulation of peptidyl-tyrosine phosphorylation [ISO]
- release of sequestered calcium ion into cytosol [ISO]
- response to morphine [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- SH3 domain binding [IPI]
- actin monomer binding [ISO, ISS]
- calcium-independent protein kinase C activity [ISO]
- enzyme activator activity [ISO]
- enzyme binding [ISO]
- ethanol binding [ISO]
- protein binding [IPI]
- protein kinase C activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [ISO]
- receptor activator activity [ISO]
- receptor binding [IPI]
- 14-3-3 protein binding [ISO]
- SH3 domain binding [IPI]
- actin monomer binding [ISO, ISS]
- calcium-independent protein kinase C activity [ISO]
- enzyme activator activity [ISO]
- enzyme binding [ISO]
- ethanol binding [ISO]
- protein binding [IPI]
- protein kinase C activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [ISO]
- receptor activator activity [ISO]
- receptor binding [IPI]
Gene Ontology Cellular Component
HIST1H1A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Glutathione depletion induces apoptosis of rat hepatocytes through activation of protein kinase C novel isoforms and dependent increase in AP-1 nuclear binding.
Treatment of isolated rat hepatocytes with the glutathione depleting agents L-buthionine-S,R-sulfoximine or diethylmaleate reproduced various cellular conditions of glutathione depletion, from moderate to severe, similar to those occurring in a wide spectrum of human liver diseases. To evaluate molecular changes and possible cellular dysfunction and damage consequent to a pathophysiologic level of GSH depletion, the effects of this condition on ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID