BAIT
ROM2
Rho family guanine nucleotide exchange factor ROM2, L000003182, YLR371W
GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p; ROM2 has a paralog, ROM1, that arose from the whole genome duplication
GO Process (6)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
DAL81
UGA35, DURL, L000000481, YIR023W
Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
GO Process (3)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly [IDA, IMP]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IMP, IPI]
- RNA polymerase II transcription factor recruiting transcription factor activity [IDA, IMP]
- RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly [IDA, IMP]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IMP, IPI]
- RNA polymerase II transcription factor recruiting transcription factor activity [IDA, IMP]
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Functional specialization of the yeast Rho1 GTP exchange factors.
Rho GTPases are regulated in complex spatiotemporal patterns that may be dependent, in part at least, on the multiplicity of their GTP exchange factors (GEFs). Here, we examine the extent of and basis for functional specialization of the Rom2 and Tus1 GEFs that activate the yeast Rho1 GTPase, the ortholog of mammalian RhoA. First, we find that these GEFs selectively ... [more]
Unknown Feb. 17, 2012; 0(0); [Pubmed: 22344253]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID