BAIT
GSN
ADF, RP23-186B18.2
gelsolin
GO Process (9)
GO Function (2)
GO Component (11)
Gene Ontology Biological Process
- actin filament polymerization [ISO]
- actin filament severing [ISO]
- actin polymerization or depolymerization [ISO]
- apoptotic process [ISO]
- cellular response to cadmium ion [ISO]
- cilium morphogenesis [ISO]
- phosphatidylinositol-mediated signaling [ISO]
- regulation of cell adhesion [ISO]
- vesicle-mediated transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PIK3C2A
Cpk-m, PI3KC2
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
GO Process (4)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength.
Osteoclasts are unique cells that utilize podosomes instead of focal adhesions for matrix attachment and cytoskeletal remodeling during motility. We have shown that osteopontin (OP) binding to the alpha(v)beta(3) integrin of osteoclast podosomes stimulated cytoskeletal reorganization and bone resorption by activating a heteromultimeric signaling complex that includes gelsolin, pp(60c-src), and phosphatidylinositol 3'-kinase. Here we demonstrate that gelsolin deficiency blocks podosome ... [more]
J. Cell Biol. Feb. 21, 2000; 148(4);665-78 [Pubmed: 10684249]
Throughput
- Low Throughput
Curated By
- BioGRID