BAIT
GLI3
AI854843, AU023367, Bph, GLI3-190, GLI3FL, Pdn, Xt, add
GLI-Kruppel family member GLI3
GO Process (87)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- T cell differentiation in thymus [IMP]
- anatomical structure development [IGI]
- anatomical structure formation involved in morphogenesis [IGI]
- anterior semicircular canal development [IMP]
- anterior/posterior pattern specification [IMP]
- artery development [IGI]
- axon guidance [IMP]
- brain development [IMP]
- branching involved in ureteric bud morphogenesis [IGI]
- branching morphogenesis of an epithelial tube [IMP]
- camera-type eye development [IGI]
- camera-type eye morphogenesis [IMP]
- cell differentiation involved in kidney development [IGI]
- central nervous system development [IGI, IMP]
- cerebral cortex radial glia guided migration [IMP]
- developmental growth [IMP]
- dorsal/ventral pattern formation [IMP]
- embryonic digestive tract development [IMP]
- embryonic digestive tract morphogenesis [IMP]
- embryonic digit morphogenesis [IGI, IMP]
- embryonic limb morphogenesis [IGI, IMP]
- embryonic morphogenesis [IMP]
- embryonic skeletal system morphogenesis [IGI]
- forebrain development [IMP]
- forebrain dorsal/ventral pattern formation [IMP]
- forebrain radial glial cell differentiation [IMP]
- frontal suture morphogenesis [IMP]
- heart development [IGI]
- hindgut morphogenesis [IGI]
- hippocampus development [IMP]
- in utero embryonic development [IMP]
- inner ear development [IGI]
- kidney development [IGI]
- lambdoid suture morphogenesis [IMP]
- lateral ganglionic eminence cell proliferation [IMP]
- lateral semicircular canal development [IMP]
- limb development [IMP, ISO]
- limb morphogenesis [IMP, ISO]
- lung development [IGI, IMP]
- mammary gland development [IMP]
- mammary gland specification [IGI]
- melanocyte differentiation [IMP]
- metanephros development [IGI]
- negative regulation of alpha-beta T cell differentiation [IMP, ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of cell differentiation [IGI]
- negative regulation of cell proliferation [IGI, IMP]
- negative regulation of neuron differentiation [IMP]
- negative regulation of smoothened signaling pathway [IMP, ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- negative thymic T cell selection [IMP, ISO]
- neural tube development [IMP]
- neuron fate commitment [IMP]
- odontogenesis of dentin-containing tooth [IGI]
- oligodendrocyte differentiation [IGI]
- optic nerve morphogenesis [IMP]
- palate development [IMP]
- pallium development [IMP]
- pattern specification process [IGI]
- positive regulation of alpha-beta T cell differentiation [IMP, ISO]
- positive regulation of chondrocyte differentiation [IMP]
- positive regulation of neuroblast proliferation [IMP]
- positive regulation of osteoblast differentiation [IGI, IMP]
- positive regulation of protein import into nucleus [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- protein processing [IDA]
- proximal/distal pattern formation [IGI, IMP]
- regulation of apoptotic process [IMP]
- regulation of cell differentiation [IGI]
- regulation of cell proliferation [IGI]
- regulation of gene expression [IGI]
- regulation of transcription, DNA-templated [IMP]
- sagittal suture morphogenesis [IMP]
- smoothened signaling pathway [IGI]
- smoothened signaling pathway involved in dorsal/ventral neural tube patterning [IGI]
- smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [IGI]
- smoothened signaling pathway involved in ventral spinal cord interneuron specification [IGI]
- spinal cord dorsal/ventral patterning [IGI]
- spinal cord motor neuron differentiation [IGI]
- subpallium development [IMP]
- telencephalon development [IMP]
- thymocyte apoptotic process [IMP, ISO]
- tongue development [IMP]
- tube development [IGI]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- beta-catenin binding [ISO]
- chromatin binding [IGI]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- beta-catenin binding [ISO]
- chromatin binding [IGI]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
SMO
E130215L21Rik, Smoh, bnb, smoothened
smoothened homolog (Drosophila)
GO Process (67)
GO Function (4)
GO Component (15)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IBA]
- anterior/posterior pattern specification [IMP]
- astrocyte activation [IMP]
- atrial septum morphogenesis [IGI]
- axon extension involved in axon guidance [ISO]
- cell development [IMP]
- cell fate specification [IMP]
- central nervous system development [IGI]
- central nervous system neuron differentiation [IMP]
- cerebellar cortex morphogenesis [IMP]
- cerebral cortex development [IMP]
- detection of cell density by contact stimulus involved in contact inhibition [ISO]
- determination of left/right asymmetry in lateral mesoderm [IMP]
- determination of left/right symmetry [IMP]
- developmental growth [IMP]
- digestive tract development [IMP]
- dorsal/ventral neural tube patterning [IMP]
- dorsal/ventral pattern formation [IMP]
- embryonic organ development [IGI]
- epithelial-mesenchymal cell signaling [IMP]
- forebrain morphogenesis [IMP]
- hair follicle morphogenesis [IMP]
- heart looping [IMP]
- heart morphogenesis [IGI]
- homeostasis of number of cells within a tissue [IDA]
- in utero embryonic development [IMP]
- mammary gland epithelial cell differentiation [IMP]
- mesenchymal to epithelial transition involved in metanephric renal vesicle formation [IMP]
- midgut development [IMP]
- multicellular organism growth [IGI, IMP]
- myoblast migration [IGI]
- negative regulation of DNA binding [IGI, IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of epithelial cell differentiation [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of hair follicle development [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neural crest cell migration [IGI]
- odontogenesis of dentin-containing tooth [IMP]
- ossification [IMP]
- osteoblast differentiation [IMP]
- pancreas morphogenesis [IMP]
- pattern specification process [IMP]
- positive regulation of branching involved in ureteric bud morphogenesis [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of hh target transcription factor activity [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of neuroblast proliferation [IGI]
- positive regulation of protein import into nucleus [IGI]
- positive regulation of smoothened signaling pathway [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein localization to nucleus [IMP]
- protein stabilization [IDA]
- regulation of gene expression [IGI]
- regulation of heart morphogenesis [IMP]
- regulation of stem cell maintenance [IMP]
- skeletal muscle fiber development [IMP]
- smoothened signaling pathway [IGI, IMP, ISO]
- smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [IMP]
- smoothened signaling pathway involved in ventral spinal cord patterning [IMP]
- somite development [IMP]
- thalamus development [IMP]
- type B pancreatic cell development [IMP]
- vasculogenesis [IMP]
- ventral midline determination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- axonal growth cone [ISO]
- caveola [ISO]
- ciliary membrane [IDA]
- cilium [IDA]
- cytoplasm [IDA, ISO]
- dendrite [ISO]
- dendritic growth cone [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IBA]
- intracellular membrane-bounded organelle [ISO]
- neuronal cell body [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
- primary cilium [IDA]
Mus musculus
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord.
The hedgehog signaling pathway organizes the developing ventral neural tube by establishing distinct neural progenitor fates along the dorsoventral axis. Smoothened (Smo) is essential for all Hedgehog (Hh) signaling, and genetic inactivation of Smo cells autonomously blocks the ability of cells to transduce the Hh signal. Using a chimeric approach, we examined the behavior of Smo null mutant neural progenitor ... [more]
Genes Dev. Nov. 15, 2002; 16(22);2849-64 [Pubmed: 12435628]
Throughput
- Low Throughput
Additional Notes
- figure 8. Ablation of Gli3 partially rescues ventral cell pattern during spinal cord development of Smo-/- embryos.
Curated By
- BioGRID