LRP6
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, IMP]
- Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- Wnt signaling pathway involved in somitogenesis [IBA]
- anterior/posterior pattern specification [IBA]
- axis elongation involved in somitogenesis [IBA]
- bone morphogenesis [IBA]
- bone remodeling [IBA]
- branching involved in mammary gland duct morphogenesis [IBA]
- canonical Wnt signaling pathway [IDA, IMP]
- canonical Wnt signaling pathway involved in neural crest cell differentiation [IC]
- canonical Wnt signaling pathway involved in regulation of cell proliferation [IC]
- cellular response to cholesterol [IMP]
- cerebellum morphogenesis [IBA]
- cerebral cortex development [IBA]
- convergent extension [IBA]
- embryonic camera-type eye morphogenesis [IBA]
- embryonic limb morphogenesis [IBA]
- embryonic pattern specification [IBA]
- embryonic retina morphogenesis in camera-type eye [IBA]
- external genitalia morphogenesis [IBA]
- face morphogenesis [IBA]
- gastrulation with mouth forming second [IBA]
- midbrain development [IBA]
- midbrain-hindbrain boundary development [IBA]
- negative regulation of protein kinase activity [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of protein serine/threonine kinase activity [IDA]
- negative regulation of smooth muscle cell apoptotic process [IMP]
- neural crest cell differentiation [IDA]
- neural crest formation [IDA]
- neural tube closure [IBA]
- odontogenesis of dentin-containing tooth [IBA]
- palate development [IBA]
- pericardium morphogenesis [IBA]
- positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell cycle [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- primitive streak formation [IBA]
- receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [IBA]
- regulation of fat cell differentiation [IBA]
- regulation of ossification [IBA]
- synaptic transmission [IBA]
- thalamus development [IBA]
- toxin transport [IMP]
- trachea cartilage morphogenesis [IBA]
Gene Ontology Molecular Function- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IPI]
- apolipoprotein binding [IBA]
- coreceptor activity involved in Wnt signaling pathway [IDA]
- frizzled binding [IPI]
- identical protein binding [IPI]
- kinase inhibitor activity [IMP]
- low-density lipoprotein receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- receptor binding [IPI]
- toxin transporter activity [IMP]
- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IPI]
- apolipoprotein binding [IBA]
- coreceptor activity involved in Wnt signaling pathway [IDA]
- frizzled binding [IPI]
- identical protein binding [IPI]
- kinase inhibitor activity [IMP]
- low-density lipoprotein receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- receptor binding [IPI]
- toxin transporter activity [IMP]
Gene Ontology Cellular Component
WNT5A
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- Wnt signaling pathway, calcium modulating pathway [IDA, IMP]
- activation of JUN kinase activity [IDA, IMP]
- activation of MAPK activity [IDA]
- activation of protein kinase B activity [IDA]
- axon guidance [ISS]
- cell fate commitment [IBA]
- cellular protein localization [IDA]
- cellular response to calcium ion [IEP]
- cellular response to interferon-gamma [IEP]
- cellular response to lipopolysaccharide [IEP]
- cellular response to retinoic acid [ISS]
- cellular response to transforming growth factor beta stimulus [IEP]
- embryonic skeletal system development [IMP]
- epithelial to mesenchymal transition [IEP]
- face development [IMP]
- genitalia development [IMP]
- hematopoietic stem cell proliferation [IDA]
- keratinocyte differentiation [IEP]
- lens development in camera-type eye [ISS]
- male gonad development [IEP]
- negative regulation of apoptotic process [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of mesenchymal cell proliferation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neuron differentiation [IBA, ISS]
- olfactory bulb interneuron development [ISS]
- optic cup formation involved in camera-type eye development [ISS]
- palate development [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell chemotaxis [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of cGMP metabolic process [IDA]
- positive regulation of chemokine biosynthetic process [IMP]
- positive regulation of cytokine secretion involved in immune response [IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of inflammatory response [IMP]
- positive regulation of interleukin-1 beta secretion [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of macrophage activation [IMP]
- positive regulation of macrophage cytokine production [IMP]
- positive regulation of neuron projection development [ISS]
- positive regulation of ossification [IMP]
- positive regulation of protein catabolic process [IGI]
- positive regulation of protein kinase C signaling [IMP]
- positive regulation of response to cytokine stimulus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of type I interferon-mediated signaling pathway [IDA]
- response to organic substance [IEP]
- wound healing [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Wnt5a regulates distinct signalling pathways by binding to Frizzled2.
Wnt5a regulates multiple intracellular signalling cascades, but how Wnt5a determines the specificity of these pathways is not well understood. This study examined whether the internalization of Wnt receptors affects the ability of Wnt5a to regulate its signalling pathways. Wnt5a activated Rac in the beta-catenin-independent pathway, and Frizzled2 (Fz2) and Ror1 or Ror2 were required for this action. Fz2 was internalized ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 1D.
Curated By
- BioGRID