BAIT
RNF115
BCA2, ZNF364
ring finger protein 115
GO Process (5)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CST3
ARMD11
cystatin C
GO Process (10)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- defense response [IDA]
- extracellular fibril organization [IGI]
- negative regulation of blood vessel remodeling [IEP]
- negative regulation of collagen catabolic process [IEP]
- negative regulation of elastin catabolic process [IMP]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of extracellular matrix disassembly [IC, IEP]
- negative regulation of peptidase activity [IDA]
- negative regulation of proteolysis [IDA]
- regulation of tissue remodeling [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Effects of partner proteins on BCA2 RING ligase activity.
BCA2 is an E3 ligase linked with hormone responsive breast cancers. We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only Rab7, tetherin, ubiquitin and UBC9 were known to directly interact with BCA2.Here, additional BCA2 binding proteins were found using yeast two-hybrid and bacterial-II-hybrid screening techniques with Human breast ... [more]
BMC Cancer Feb. 10, 2012; 12(0);63 [Pubmed: 22315970]
Throughput
- Low Throughput
Curated By
- BioGRID